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    ppk12 pickpocket 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppk12provided by FlyBase
    Official Full Name
    pickpocket 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0034730
    Locus tag
    Dmel_CG10972
    See related
    AllianceGenome:FB:FBgn0034730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10972; Dmel\CG10972; Ppk12; PPK12
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic/larval tracheal dorsal trunk and tracheal tip cell. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppk12 in Genome Data Viewer
    Location:
    58E1-58E1; 2-100 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22427479..22429584)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18314984..18317089)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene rad50 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila hygrosensation requires the TRP channels water witch and nanchung. Liu L, et al. Nature, 2007 Nov 8. PMID 17994098
    2. Two Drosophila DEG/ENaC channel subunits have distinct functions in gustatory neurons that activate male courtship. Liu T, et al. J Neurosci, 2012 Aug 22. PMID 22915128, Free PMC Article
    3. An insecticide target in mechanoreceptor neurons. Qiao X, et al. Sci Adv, 2022 Nov 25. PMID 36417522, Free PMC Article
    4. Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance. Liu L, et al. Proc Natl Acad Sci U S A, 2003 Feb 18. PMID 12571352, Free PMC Article
    5. Contribution of Drosophila DEG/ENaC genes to salt taste. Liu L, et al. Neuron, 2003 Jul 3. PMID 12848938

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pickpocket 12
    Names
    CG10972-PA
    ppk12-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22427479..22429584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137828.1 → NP_611672.1  pickpocket 12 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W250
      Related
      FBpp0071741, FBtr0071830
      Conserved Domains (2) summary
      TIGR00867
      Location:28 → 499
      deg-1; degenerin
      pfam00858
      Location:29 → 499
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W250 Q9W250

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