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    ana3 anastral spindle 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36341, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ana3provided by FlyBase
    Official Full Name
    anastral spindle 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0266111
    Locus tag
    Dmel_CG13162
    See related
    AllianceGenome:FB:FBgn0266111
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ana3; CG13162; Dmel\CG13162; l(2)SH0558
    Summary
    Involved in centriole replication; centriole-centriole cohesion; and ciliary basal body organization. Located in centriole; ciliary basal body; and ring centriole. Is expressed in spermatozoon. Used to study dilated cardiomyopathy. Orthologous to human RTTN (rotatin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ana3 in Genome Data Viewer
    Location:
    48F11-49A1; 2-67 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12344983..12351325)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8232488..8238830)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Deneddylase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy. Chun YW, et al. Circulation, 2023 Apr 25. PMID 36970983, Free PMC Article
    2. Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster. Cho DG, et al. Mol Cells, 2021 Jan 31. PMID 33510049, Free PMC Article
    3. A Likelihood Approach for Uncovering Selective Sweep Signatures from Haplotype Data. Harris AM, et al. Mol Biol Evol, 2020 Oct 1. PMID 32392293, Free PMC Article
    4. Identification of a proctolin preprohormone gene (Proct) of Drosophila melanogaster: expression and predicted prohormone processing. Taylor CA, et al. J Neurobiol, 2004 Feb 15. PMID 14750150
    5. Superresolution characterization of core centriole architecture. Tian Y, et al. J Cell Biol, 2021 Apr 5. PMID 33533934, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster.
      Title: Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster.
    2. Ana3 defines a conserved family of centriolar proteins and plays an important part in ensuring the structural integrity of centrioles and basal bodies
      Title: Ana3 is a conserved protein required for the structural integrity of centrioles and basal bodies.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centriole assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole-centriole cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole-centriole cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ciliary basal body organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ciliary basal body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ring centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anastral spindle 3
    Names
    CG13162-PA
    ana3-PA
    anastral spindle phenotype 3
    lethal (2) SH0558

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12344983..12351325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136921.2 → NP_610765.1  anastral spindle 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610765.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z8X3
      Related
      FBpp0087015
      Conserved Domains (1) summary
      pfam14726
      Location:25 → 120
      RTTN_N; Rotatin, an armadillo repeat protein, centriole functioning
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8X3.1 A1Z8X3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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