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    fh frataxin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31845, updated on 9-Dec-2024

    Summary

    Official Symbol
    fhprovided by FlyBase
    Official Full Name
    frataxinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030092
    Locus tag
    Dmel_CG8971
    See related
    AllianceGenome:FB:FBgn0030092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT09528; CG8971; dfh; Dfh; DFH; Dmel\CG8971; Fh; X25
    Summary
    Enables ferrous iron binding activity and iron chaperone activity. Involved in several processes, including determination of adult lifespan; positive regulation of ecdysteroid biosynthetic process; and positive regulation of oxidative phosphorylation. Located in mitochondrion. Is expressed in organism. Used to study Friedreich ataxia and Friedreich ataxia 1. Human ortholog(s) of this gene implicated in Friedreich ataxia; Friedreich ataxia 1; glioblastoma; and type 2 diabetes mellitus. Orthologous to human FXN (frataxin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    Location:
    8C14-8C14; 1-26 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9148080..9149071, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9042113..9043104, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44517 Neighboring gene uncharacterized protein Neighboring gene Brahma associated protein 111kD Neighboring gene Histone H3.3B

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding  
    enables ferric iron binding  
    enables ferric iron binding  
    enables ferrous iron binding  
    enables ferrous iron binding PubMed 
    enables ferroxidase activity  
    enables ferroxidase activity  
    enables ferroxidase activity  
    enables iron chaperone activity  
    enables iron chaperone activity PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior PubMed 
    involved_in axonal transport of mitochondrion PubMed 
    involved_in determination of adult lifespan PubMed 
    involved_in intracellular iron ion homeostasis  
    involved_in iron incorporation into metallo-sulfur cluster  
    involved_in iron-sulfur cluster assembly  
    involved_in iron-sulfur cluster assembly PubMed 
    involved_in lipid catabolic process PubMed 
    involved_in positive regulation of ecdysteroid biosynthetic process PubMed 
    involved_in positive regulation of heart contraction PubMed 
    involved_in positive regulation of oxidative phosphorylation PubMed 
    involved_in regulation of mitochondrial membrane potential PubMed 
    involved_in response to hydrogen peroxide PubMed 
    involved_in response to iron ion PubMed 
    involved_in response to oxidative stress PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial [2Fe-2S] assembly complex PubMed 
    located_in mitochondrial matrix  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    frataxin
    Names
    CG8971-PA
    drosophila frataxin homolog
    fh-PA
    frataxin homolog
    frataxin homologue
    frataxin-like
    NP_511094.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9148080..9149071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078539.3 → NP_511094.1  frataxin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GQQ7, Q9W385
      Related
      FBpp0071283
      Conserved Domains (1) summary
      TIGR03422
      Location:72 → 173
      mito_frataxin; frataxin
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