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    sr stripe [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42162, updated on 17-Dec-2024

    Summary

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    Official Symbol
    srprovided by FlyBase
    Official Full Name
    stripeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003499
    Locus tag
    Dmel_CG7847
    See related
    AllianceGenome:FB:FBgn0003499
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7847; Dmel\CG7847; l(3)03999; l(3)06948; l(3)06948b; Sr; SrB; Stripe
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SUMO ligase activity. Involved in several processes, including ectoderm development; epithelial cell migration, open tracheal system; and germ-band shortening. Is expressed in several structures, including denticle row; imaginal disc; muscle attachment site; region of integument; and sensory organ cell. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1) and EGR3 (early growth response 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    90E4-90F1; 3-62 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18090803..18135583)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13916525..13961305)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene heartless Neighboring gene bard Neighboring gene transfer RNA:Glycine-TCC 1-3 Neighboring gene transfer RNA:Glycine-TCC 1-4 Neighboring gene long non-coding RNA:CR45103 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a Drosophila muscle development gene with structural homology to mammalian early growth response transcription factors. Lee JC, et al. Proc Natl Acad Sci U S A, 1995 Oct 24. PMID 7479781, Free PMC Article
    2. Neurophysiology of flight in wild-type and a mutant Drosophila. Levine JD, et al. Proc Natl Acad Sci U S A, 1973 Apr. PMID 4197927, Free PMC Article
    3. Development of an indirect flight muscle in a muscle-specific mutant of Drosophila melanogaster. Costello WJ, et al. Dev Biol, 1986 Nov. PMID 3095162
    4. Two isoforms of the Drosophila RNA binding protein, how, act in opposing directions to regulate tendon cell differentiation. Nabel-Rosen H, et al. Dev Cell, 2002 Feb. PMID 11832244
    5. The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera. Costa M, et al. Dev Biol, 2014 Apr 15. PMID 24384389, Free PMC Article

    See all (206) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cell assembly analysis of neural circuits for innate behavior in Drosophila melanogaster using an immediate early gene stripe/egr-1.
      Title: Cell assembly analysis of neural circuits for innate behavior in Drosophila melanogaster using an immediate early gene stripe/egr-1.
    2. The positioning and differentiation of the migrating chordotonal organs are instructed by Stripe.
      Title: The proprioceptive and contractile systems in Drosophila are both patterned by the EGR family transcription factor Stripe.
    3. role in providing cues synergizing with branchless to direct tracheal cell migration
      Title: Stripe provides cues synergizing with branchless to direct tracheal cell migration.
    4. the transition to the mature differentiation state is triggered post-transcriptionally by enhanced production of the stripeA splice variant, which is typical of the tendon mature state
      Title: Muscle-dependent maturation of tendon cells is induced by post-transcriptional regulation of stripeA.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell migration, open tracheal system IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-band shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pigment metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stripe
    Names
    CG7847-PA
    CG7847-PB
    CG7847-PC
    CG7847-PD
    CG7847-PE
    STRIPE
    StripeB
    sr-PA
    sr-PB
    sr-PC
    sr-PD
    sr-PE
    striped

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18090803..18135583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079671.2 → NP_524395.2  stripe, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524395.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JP26, Q9VED3
      Related
      FBpp0082966, FBtr0083542
      Conserved Domains (3) summary
      sd00017
      Location:1038 → 1060
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1036 → 1060
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1080 → 1105
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001275764.1 → NP_001262693.1  stripe, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262693.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGW2, Q7JP26
      Conserved Domains (3) summary
      sd00017
      Location:1038 → 1060
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1036 → 1060
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1080 → 1105
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001300455.1 → NP_001287384.1  stripe, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24162, Q24163, Q8IN91
      Conserved Domains (3) summary
      sd00017
      Location:758 → 780
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:756 → 780
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:800 → 825
      zf-H2C2_2; Zinc-finger double domain

    4. NM_169786.3 → NP_732289.1  stripe, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732289.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24162, Q24163, Q8IN91
      Related
      FBpp0082967
      Conserved Domains (3) summary
      sd00017
      Location:758 → 780
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:756 → 780
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:800 → 825
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001170172.2 → NP_001163643.1  stripe, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIP0
      Conserved Domains (3) summary
      sd00017
      Location:569 → 591
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:567 → 591
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:611 → 636
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGW2 A0A0B4KGW2
    E1JIP0 E1JIP0
    Q24163 Q24163
    Q7JP26 Q7JP26
    Q8IN91 Q8IN91
    Q9VED3 Q9VED3

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