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    alpha-Est4 alpha-Esterase-4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40906, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpha-Est4provided by FlyBase
    Official Full Name
    alpha-Esterase-4provided by FlyBase
    Primary source
    FLYBASE:FBgn0015572
    Locus tag
    Dmel_CG1082
    See related
    AllianceGenome:FB:FBgn0015572
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aE4; alphaE4; C; CG1082; DmalphaE4; Dmel\CG1082; FBgn0015572
    Summary
    Predicted to enable carboxylesterase activity. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpha-Est4 in Genome Data Viewer
    Location:
    84D9-84D9; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7536687..7538615, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3362409..3364337, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Tubulin at 84D Neighboring gene alpha-Esterase-5 Neighboring gene antisense RNA:CR46128 Neighboring gene alpha-Esterase-3 Neighboring gene alpha-Esterase-2 Neighboring gene antisense RNA:CR46129

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carboxyl/cholinesterases: a case study of the evolution of a successful multigene family. Oakeshott JG, et al. Bioessays, 1999 Dec. PMID 10580988
    2. Developmental expression and gene/enzyme identifications in the alpha esterase gene cluster of Drosophila melanogaster. Campbell PM, et al. Insect Mol Biol, 2003 Oct. PMID 12974951
    3. Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster. Robin C, et al. J Mol Evol, 1996 Sep. PMID 8703090
    4. Reconstructing the diversification of alpha-esterases: comparing the gene clusters of Drosophila buzzatii and D. melanogaster. de Q Robin GC, et al. J Mol Evol, 2000 Aug. PMID 10948271
    5. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7. Birner-Gruenberger R, et al. Insect Biochem Mol Biol, 2012 Mar. PMID 22198472

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-Esterase-4
    Names
    CG1082-PA
    alpha-Est4-PA
    fragment C
    NP_524266.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7536687..7538615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079542.4 → NP_524266.1  alpha-Esterase-4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524266.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24197, Q9VIC0
      Related
      FBpp0081070
      Conserved Domains (2) summary
      COG0657
      Location:104 → 219
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      cl21494
      Location:7 → 529
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24197 Q24197
    Q9VIC0 Q9VIC0

    Gene LinkOut

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