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    Mat1 Menage a trois 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mat1provided by FlyBase
    Official Full Name
    Menage a trois 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0024956
    Locus tag
    Dmel_CG7614
    See related
    AllianceGenome:FB:FBgn0024956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AT-1; CG7614; Dmel\CG7614; MAT1
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in DNA repair; regulation of transcription by RNA polymerase II; and transcription initiation at RNA polymerase II promoter. Part of transcription factor TFIIH holo complex. Is expressed in organism. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mat1 in Genome Data Viewer
    Location:
    47B9-47B9; 2-63 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10738617..10739829, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6626122..6627334, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rab3 Neighboring gene Carbonic anhydrase 13 Neighboring gene D-amino acid oxidase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43605 Neighboring gene long non-coding RNA:CR44299

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xpd/Ercc2 regulates CAK activity and mitotic progression. Chen J, et al. Nature, 2003 Jul 10. PMID 12853965
    2. T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity. Larochelle S, et al. EMBO J, 2001 Jul 16. PMID 11447116, Free PMC Article
    3. TFIIH trafficking and its nuclear assembly during early Drosophila embryo development. Aguilar-Fuentes J, et al. J Cell Sci, 2006 Sep 15. PMID 16940351
    4. Secrets of a double agent: CDK7 in cell-cycle control and transcription. Fisher RP. J Cell Sci, 2005 Nov 15. PMID 16280550
    5. Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase. Nag RN, et al. Development, 2018 Jan 25. PMID 29361561, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of carboxy-terminal domain protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH holo complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    menage a trois 1
    Names
    CG7614-PA
    Mat1-PA
    menage a trois 1 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10738617..10739829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136761.3 → NP_610605.1  menage a trois 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610605.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KPG8, Q8SX08
      Related
      FBpp0087350
      Conserved Domains (4) summary
      TIGR00570
      Location:1 → 313
      cdk7; CDK-activating kinase assembly factor MAT1
      cl03951
      Location:66 → 175
      CDC37_N; Cdc37 N terminal kinase binding
      cl12057
      Location:127 → 215
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
      cl17238
      Location:3 → 47
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KPG8 Q7KPG8
    Q8SX08 Q8SX08

    Gene LinkOut

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