U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    east enhanced adult sensory threshold [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46006, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    eastprovided by FlyBase
    Official Full Name
    enhanced adult sensory thresholdprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261954
    Locus tag
    Dmel_CG4399
    See related
    AllianceGenome:FB:FBgn0261954
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.224; CG4399; Dmel\CG4399; East; EAST; EG:133E12.4; l(1)G0014; l(1)G0500; su(w[sp])
    Summary
    Involved in several processes, including meiotic nuclear division; metamorphosis; and regulation of metaphase plate congression. Located in nucleoplasm and polytene chromosome. Is expressed in several structures, including eye disc morphogenetic furrow; eye-antennal disc; neurogenic region; presumptive embryonic/larval central nervous system; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See east in Genome Data Viewer
    Location:
    2C2-2C4; 1-0.5 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2010860..2024647)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1904893..1918680)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45478 Neighboring gene mir-2496 stem loop Neighboring gene alpha actinin Neighboring gene mir-4954 stem loop Neighboring gene ultraspiracle Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Nuclear matrix protein EAST is involved in regulation of transcription of the yellow gene in Drosophila melanogaster. Mel'nikova LS, et al. Dokl Biol Sci, 2007 Jul-Aug. PMID 17929676
    2. Induced somatic and germinal reversion of the white-spotted-1 insertional mutant phenotype in Drosophila melanogaster. Soriano S, et al. Mutagenesis, 1998 Mar. PMID 9568595
    3. LTR sequence of the MDG4 retrotransposon contains the MAD protein binding site that affects the east-dependent repression. Golovnin AK, et al. Dokl Biochem Biophys, 2017 Mar. PMID 28510129
    4. Neural circuit mechanisms underlying context-specific halting in Drosophila. Sapkal N, et al. Nature, 2024 Oct. PMID 39358520, Free PMC Article
    5. The extrachromosomal East protein of Drosophila can associate with polytene chromosomes and regulate gene expression. Wasser M, et al. PLoS One, 2007 May 2. PMID 17476334, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the spindle matrix complex, including Chromator/Chriz (Chro), Megator (Mtor), and enhanced adult sensory threshold (East), has a novel nuclear function in reactivation of neural stem cells (NSCs).
      Title: An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins.
    2. propose that EAST acts as an ion sensor that modulates gene expression in response to changing intracellular ion concentrations
      Title: The extrachromosomal East protein of Drosophila can associate with polytene chromosomes and regulate gene expression.
    3. EAST protein is involved in regulation of the yellow gene in D. melanogaster.
      Title: Nuclear matrix protein EAST is involved in regulation of transcription of the yellow gene in Drosophila melanogaster.
    4. Chro activates and east inhibits processes and genes involved in tissue destruction and remodeling.
      Title: EAST and Chromator control the destruction and remodeling of muscles during Drosophila metamorphosis.
    5. Megator and EAST interact to form a nuclear endoskeleton and as well are important components of the putative spindle matrix complex during mitosis
      Title: EAST interacts with Megator and localizes to the putative spindle matrix during mitosis in Drosophila.
    6. propose that EAST constitutes a component of a nucleoskeleton that helps to constrain the mobility of chromosomes in interphase, mitosis and meiosis
      Title: The Drosophila EAST protein associates with a nuclear remnant during mitosis and constrains chromosome mobility.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in achiasmate meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metamorphosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    enhanced adult sensory threshold
    Names
    CG4399-PB
    CG4399-PC
    CG4399-PD
    CG4399-PE
    CG4399-PF
    CG4399-PG
    east-PB
    east-PC
    east-PD
    east-PE
    east-PF
    east-PG
    enhanced adult salt tolerance
    suppressor of white-spotted

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2010860..2024647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258555.1 → NP_001245484.1  enhanced adult sensory threshold, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245484.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z755, O46048
      Conserved Domains (1) summary
      PHA03307
      Location:295 → 535
      PHA03307; transcriptional regulator ICP4; Provisional

    2. NM_001201601.2 → NP_001188530.1  enhanced adult sensory threshold, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188530.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z755, Q7KW02
      Conserved Domains (1) summary
      PHA03307
      Location:295 → 535
      PHA03307; transcriptional regulator ICP4; Provisional

    3. NM_080125.5 → NP_524864.2  enhanced adult sensory threshold, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524864.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z755, Q7KW02
      Related
      FBpp0070312
      Conserved Domains (1) summary
      PHA03307
      Location:295 → 535
      PHA03307; transcriptional regulator ICP4; Provisional

    4. NM_001258556.2 → NP_001245485.1  enhanced adult sensory threshold, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245485.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z755, O46048
      Conserved Domains (1) summary
      PHA03307
      Location:295 → 535
      PHA03307; transcriptional regulator ICP4; Provisional

    5. NM_001201602.2 → NP_001188531.1  enhanced adult sensory threshold, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188531.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z755, Q7KW02
      Conserved Domains (1) summary
      PHA03307
      Location:295 → 535
      PHA03307; transcriptional regulator ICP4; Provisional

    6. NM_001297869.1 → NP_001284798.1  enhanced adult sensory threshold, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284798.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z755, X2JDX3
      Conserved Domains (1) summary
      PHA03307
      Location:295 → 535
      PHA03307; transcriptional regulator ICP4; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46048 O46048
    Q7KW02 Q7KW02
    Q8MQW2 Q8MQW2
    Q9NGR9 Q9NGR9
    X2JDX3 X2JDX3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools