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    Rpn7 Regulatory particle non-ATPase 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42641, updated on 17-Dec-2024

    Summary

    Official Symbol
    Rpn7provided by FlyBase
    Official Full Name
    Regulatory particle non-ATPase 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0028688
    Locus tag
    Dmel_CG5378
    See related
    AllianceGenome:FB:FBgn0028688
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    141231_at; anon-WO0172774.103; anon-WO0172774.106; CG5378; Dmel\CG5378; p42A; rpn7; S10a
    Summary
    Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in adult head and organism. Used to study neurodegenerative disease. Orthologous to human PSMD6 (proteasome 26S subunit, non-ATPase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Rpn7 in Genome Data Viewer
    Location:
    94A15-94A15; 3-74 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22460662..22462054, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18286384..18287776, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Adaptor Protein complex 2, mu subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    part_of proteasome complex PubMed 
    part_of proteasome regulatory particle  
    part_of proteasome regulatory particle PubMed 
    part_of proteasome regulatory particle PubMed 
    part_of proteasome regulatory particle, lid subcomplex PubMed 

    General protein information

    Preferred Names
    regulatory particle non-ATPase 7
    Names
    CG5378-PA
    Rpn7-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22460662..22462054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142791.3 → NP_651048.1  regulatory particle non-ATPase 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3G7
      Related
      FBpp0083687
      Conserved Domains (3) summary
      COG5187
      Location:15 → 382
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:254 → 358
      PCI; PCI domain
      pfam10602
      Location:66 → 239
      RPN7; 26S proteasome subunit RPN7
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