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    LUZP1 leucine zipper protein 1 [ Homo sapiens (human) ]

    Gene ID: 7798, updated on 10-Dec-2024

    Summary

    Official Symbol
    LUZP1provided by HGNC
    Official Full Name
    leucine zipper protein 1provided by HGNC
    Primary source
    HGNC:HGNC:14985
    See related
    Ensembl:ENSG00000169641 MIM:601422; AllianceGenome:HGNC:14985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LUZP
    Summary
    This gene encodes a protein that contains a leucine zipper motif. The exact function of the encoded protein is not known. In mice this gene affects neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
    Expression
    Ubiquitous expression in small intestine (RPKM 10.5), duodenum (RPKM 8.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LUZP1 in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23083642..23178122, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (22909316..23003819, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23410135..23504182, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:23336854-23338053 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23345765-23346452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23346453-23347138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 356 Neighboring gene testis expressed 46 Neighboring gene lysine demethylase 1A Neighboring gene microRNA 3115 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23459884-23460190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23466860-23467360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23467361-23467861 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23494055-23494586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23494587-23495118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 357 Neighboring gene RNA, U6 small nuclear 514, pseudogene Neighboring gene RNA, U6 small nuclear 135, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 407 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 408 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:23515051-23516250 Neighboring gene 5-hydroxytryptamine receptor 1D Neighboring gene MPRA-validated peak115 silencer Neighboring gene ribosomal protein L29 pseudogene 6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35697, KIAA0601

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apical constriction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in artery development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural fold bending IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein complex stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ventricular septum development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of CERF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142546.4NP_001136018.1  leucine zipper protein 1

      See identical proteins and their annotated locations for NP_001136018.1

      Status: REVIEWED

      Source sequence(s)
      AL031428, AL049576
      Consensus CDS
      CCDS30628.1
      UniProtKB/Swiss-Prot
      Q5TH93, Q86V48, Q8N4X3, Q8TEH1
      Related
      ENSP00000516586.2, ENST00000706844.2
      Conserved Domains (1) summary
      COG0419
      Location:9355
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    2. NM_001395461.1NP_001382390.1  leucine zipper protein 1

      Status: REVIEWED

      Source sequence(s)
      AL031428, AL049576
      Consensus CDS
      CCDS30628.1
      UniProtKB/Swiss-Prot
      Q5TH93, Q86V48, Q8N4X3, Q8TEH1
      Conserved Domains (1) summary
      COG0419
      Location:9355
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    3. NM_001395462.2NP_001382391.1  leucine zipper protein 1

      Status: REVIEWED

      Source sequence(s)
      AL031428, AL049576
      Consensus CDS
      CCDS30628.1
      UniProtKB/Swiss-Prot
      Q5TH93, Q86V48, Q8N4X3, Q8TEH1
      Related
      ENSP00000303758.4, ENST00000302291.9
      Conserved Domains (1) summary
      COG0419
      Location:9355
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    4. NM_033631.5NP_361013.3  leucine zipper protein 1

      See identical proteins and their annotated locations for NP_361013.3

      Status: REVIEWED

      Source sequence(s)
      AL031428, AL049576
      Consensus CDS
      CCDS30628.1
      UniProtKB/Swiss-Prot
      Q5TH93, Q86V48, Q8N4X3, Q8TEH1
      Related
      ENSP00000428061.2, ENST00000471849.6
      Conserved Domains (1) summary
      COG0419
      Location:9355
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      23083642..23178122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429992.1XP_047285948.1  leucine zipper protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5TH93, Q86V48, Q8N4X3, Q8TEH1
    2. XM_047429993.1XP_047285949.1  leucine zipper protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5TH93, Q86V48, Q8N4X3, Q8TEH1
    3. XM_047429989.1XP_047285945.1  leucine zipper protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5TH93, Q86V48, Q8N4X3, Q8TEH1
    4. XM_011542090.4XP_011540392.1  leucine zipper protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011540392.1

      UniProtKB/Swiss-Prot
      Q5TH93, Q86V48, Q8N4X3, Q8TEH1
      Conserved Domains (1) summary
      COG0419
      Location:9355
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    5. XM_047429987.1XP_047285943.1  leucine zipper protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5TH93, Q86V48, Q8N4X3, Q8TEH1
    6. XM_047429988.1XP_047285944.1  leucine zipper protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5TH93, Q86V48, Q8N4X3, Q8TEH1
    7. XM_047429991.1XP_047285947.1  leucine zipper protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5TH93, Q86V48, Q8N4X3, Q8TEH1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      22909316..23003819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338652.1XP_054194627.1  leucine zipper protein 1 isoform X1

    2. XM_054338651.1XP_054194626.1  leucine zipper protein 1 isoform X1

    3. XM_054338649.1XP_054194624.1  leucine zipper protein 1 isoform X1

    4. XM_054338646.1XP_054194621.1  leucine zipper protein 1 isoform X1

    5. XM_054338647.1XP_054194622.1  leucine zipper protein 1 isoform X1

    6. XM_054338648.1XP_054194623.1  leucine zipper protein 1 isoform X1

    7. XM_054338650.1XP_054194625.1  leucine zipper protein 1 isoform X1