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    STAMBPL1 STAM binding protein like 1 [ Homo sapiens (human) ]

    Gene ID: 57559, updated on 27-Nov-2024

    Summary

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    Official Symbol
    STAMBPL1provided by HGNC
    Official Full Name
    STAM binding protein like 1provided by HGNC
    Primary source
    HGNC:HGNC:24105
    See related
    Ensembl:ENSG00000138134 MIM:612352; AllianceGenome:HGNC:24105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMSH-FP; AMSH-LP; ALMalpha; bA399O19.2
    Summary
    Enables K63-linked deubiquitinase activity. Involved in cellular response to L-leucine and positive regulation of TORC1 signaling. Located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal (RPKM 7.5), testis (RPKM 6.2) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STAMBPL1 in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88880245..88923487)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89763682..89807429)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90640002..90683244)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3725 Neighboring gene lipase family member M Neighboring gene ankyrin repeat domain 22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3726 Neighboring gene uncharacterized LOC124902551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3727 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:90641731-90642930 Neighboring gene pentatricopeptide repeat domain 2 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3731 Neighboring gene ACTA2 antisense RNA 1 Neighboring gene actin alpha 2, smooth muscle Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:90749708-90750219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:90750220-90750730 Neighboring gene Fas cell surface death receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3733 Neighboring gene FAS antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Quantum Mechanics and Molecular Mechanics Study of the Catalytic Mechanism of Human AMSH-LP Domain Deubiquitinating Enzymes. Zhu W, et al. Biochemistry, 2015 Aug 25. PMID 26256234
    2. Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway. Wang Z, et al. Biol Direct, 2024 Feb 28. PMID 38419066, Free PMC Article
    3. STAMBPL1, transcriptionally regulated by SREBP1, promotes malignant behaviors of hepatocellular carcinoma cells via Wnt/β-catenin signaling pathway. Jin J, et al. Mol Carcinog, 2024 Nov. PMID 39150093
    4. A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells. Kitajima K, et al. Biochem Biophys Res Commun, 2003 Sep 12. PMID 12943674
    5. STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression. Liu R, et al. Oncogene, 2022 Apr. PMID 35236965

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STAMBPL1, transcriptionally regulated by SREBP1, promotes malignant behaviors of hepatocellular carcinoma cells via Wnt/beta-catenin signaling pathway.
      Title: STAMBPL1, transcriptionally regulated by SREBP1, promotes malignant behaviors of hepatocellular carcinoma cells via Wnt/β-catenin signaling pathway.
    2. Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway.
      Title: Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway.
    3. STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression.
      Title: STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression.
    4. E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
      Title: E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
    5. Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell death.
      Title: Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell death.
    6. Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1.
      Title: Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1.
    7. The Long Non-Coding RNA NEAT1 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating miR-103a/ STAMBPL1 Axis.
      Title: The Long Non-Coding RNA NEAT1 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating miR-103a/ STAMBPL1 Axis.
    8. Systematic analysis reveals a functional role for STAMBPL1 in the epithelial-mesenchymal transition process across multiple carcinomas.
      Title: Systematic analysis reveals a functional role for STAMBPL1 in the epithelial-mesenchymal transition process across multiple carcinomas.
    9. Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation.
      Title: Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation.
    10. STAMBPL1 depletion induces prostate cancer cell apoptosis by promoting XIAP lysosomal degradation.
      Title: Targeting the deubiquitinase STAMBPL1 triggers apoptosis in prostate cancer cells by promoting XIAP degradation.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31524, KIAA1373

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables K63-linked deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal-dependent deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AMSH-like protease
    Names
    associated molecule with the SH3 domain of STAM (AMSH) - Family Protein
    associated molecule with the SH3 domain of STAM (AMSH) like protein
    NP_065850.1
    XP_006717993.1
    XP_011538285.1
    XP_011538287.1
    XP_016871945.1
    XP_016871946.1
    XP_016871947.1
    XP_047281507.1
    XP_047281508.1
    XP_047281509.1
    XP_047281510.1
    XP_047281511.1
    XP_054222371.1
    XP_054222372.1
    XP_054222373.1
    XP_054222374.1
    XP_054222375.1
    XP_054222376.1
    XP_054222377.1
    XP_054222378.1
    XP_054222379.1
    XP_054222380.1
    XP_054222381.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020799.4 → NP_065850.1  AMSH-like protease

      See identical proteins and their annotated locations for NP_065850.1

      Status: VALIDATED

      Source sequence(s)
      AK056086, AW006657, CD244526
      Consensus CDS
      CCDS7391.1
      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
      UniProtKB/TrEMBL
      B3KS69
      Related
      ENSP00000360994.3, ENST00000371926.8
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120 → 198
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      88880245..88923487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425551.1 → XP_047281507.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    2. XM_011539985.3 → XP_011538287.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_011538287.1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
      UniProtKB/TrEMBL
      B3KS69
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120 → 198
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. XM_006717930.4 → XP_006717993.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_006717993.1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
      UniProtKB/TrEMBL
      B3KS69
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120 → 198
      GBP_C; Guanylate-binding protein, C-terminal domain

    4. XM_047425553.1 → XP_047281509.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    5. XM_011539983.2 → XP_011538285.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_011538285.1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
      UniProtKB/TrEMBL
      B3KS69
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120 → 198
      GBP_C; Guanylate-binding protein, C-terminal domain

    6. XM_047425555.1 → XP_047281511.1  AMSH-like protease isoform X2

    7. XM_047425552.1 → XP_047281508.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    8. XM_017016456.2 → XP_016871945.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
      UniProtKB/TrEMBL
      B3KS69
      Conserved Domains (3) summary
      cd08066
      Location:266 → 436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28 → 129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120 → 198
      GBP_C; Guanylate-binding protein, C-terminal domain

    9. XM_017016457.3 → XP_016871946.1  AMSH-like protease isoform X2

      UniProtKB/TrEMBL
      B3KS69

    10. XM_047425554.1 → XP_047281510.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    11. XM_017016458.2 → XP_016871947.1  AMSH-like protease isoform X3

      UniProtKB/TrEMBL
      B3KR00
      Conserved Domains (2) summary
      cd08066
      Location:160 → 330
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      COG0544
      Location:13 → 91
      Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      89763682..89807429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366396.1 → XP_054222371.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    2. XM_054366400.1 → XP_054222375.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    3. XM_054366401.1 → XP_054222376.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    4. XM_054366402.1 → XP_054222377.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    5. XM_054366398.1 → XP_054222373.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    6. XM_054366405.1 → XP_054222380.1  AMSH-like protease isoform X2

    7. XM_054366399.1 → XP_054222374.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    8. XM_054366397.1 → XP_054222372.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    9. XM_054366404.1 → XP_054222379.1  AMSH-like protease isoform X2

    10. XM_054366403.1 → XP_054222378.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

    11. XM_054366406.1 → XP_054222381.1  AMSH-like protease isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96FJ0.2 GenPept UniProtKB/Swiss-Prot:Q96FJ0

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