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    VIPR1 vasoactive intestinal peptide receptor 1 [ Homo sapiens (human) ]

    Gene ID: 7433, updated on 27-Nov-2024

    Summary

    Official Symbol
    VIPR1provided by HGNC
    Official Full Name
    vasoactive intestinal peptide receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:12694
    See related
    Ensembl:ENSG00000114812 MIM:192321; AllianceGenome:HGNC:12694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    II; HVR1; RDC1; V1RG; VIPR; VIRG; VAPC1; VPAC1; VPAC1R; VIP-R-1; VPCAP1R; PACAP-R2; PACAP-R-2
    Summary
    This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Broad expression in lung (RPKM 17.1), duodenum (RPKM 12.7) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See VIPR1 in Genome Data Viewer
    Location:
    3p22.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (42489299..42537568)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (42507314..42555561)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42530791..42579060)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:42411131-42411759 Neighboring gene NANOG hESC enhancer GRCh37_chr3:42426849-42427356 Neighboring gene lysozyme like 4 Neighboring gene uncharacterized LOC124909371 Neighboring gene ribosomal protein L35a pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19745 Neighboring gene uncharacterized LOC124909372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:42542633-42543206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14244 Neighboring gene Sharpr-MPRA regulatory region 5178 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:42566136-42566306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42574871-42575372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42581415-42581916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42581917-42582416 Neighboring gene VIPR1 antisense RNA 1 Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:42622926-42623752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14246 Neighboring gene SS18 like 2 Neighboring gene ZBTB47 and NKTR antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:42672544-42673392 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:42673393-42674241 Neighboring gene natural killer cell triggering receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19748

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 has sequence similarity to the natural ligand for VPAC1 and it can activate this receptor directly PubMed
    Tat tat HIV-1 Tat downregulates the expression of vasoactive intestinal peptide receptor 1 (VIPR1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ41949

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables pituitary adenylate cyclase-activating polypeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables vasoactive intestinal polypeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables vasoactive intestinal polypeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vasoactive intestinal polypeptide receptor 1
    Names
    PACAP type II receptor
    VIP and PACAP receptor 1
    VIP receptor, type I
    VPAC1 receptor
    pituitary adenylate cyclase activating polypeptide receptor, type II
    type 1 vasoactive intestinal peptide receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030371.1 RefSeqGene

      Range
      18345..53270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001251882.2NP_001238811.1  vasoactive intestinal polypeptide receptor 1 isoform 2

      See identical proteins and their annotated locations for NP_001238811.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC092047, AK056819, AK298115, BU681817
      Consensus CDS
      CCDS58828.1
      Related
      ENSP00000394950.1, ENST00000433647.5
      Conserved Domains (2) summary
      smart00008
      Location:1887
      HormR; Domain present in hormone receptors
      pfam00002
      Location:98343
      7tm_2; 7 transmembrane receptor (Secretin family)
    2. NM_001251883.2NP_001238812.1  vasoactive intestinal polypeptide receptor 1 isoform 3

      See identical proteins and their annotated locations for NP_001238812.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, uses a downstream start codon, and has multiple differences in the coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC092047, AK293548, BU681817
      Consensus CDS
      CCDS58829.1
      UniProtKB/Swiss-Prot
      P32241
      Related
      ENSP00000415371.2, ENST00000438259.6
      Conserved Domains (1) summary
      cl21561
      Location:55174
      7tm_4; Olfactory receptor
    3. NM_001251884.2NP_001238813.1  vasoactive intestinal polypeptide receptor 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC092047, AK294609, AK298115, BU681817
      Consensus CDS
      CCDS58827.1
      UniProtKB/Swiss-Prot
      P32241
      UniProtKB/TrEMBL
      B4DNY6
      Related
      ENSP00000445701.1, ENST00000543411.5
      Conserved Domains (2) summary
      smart00008
      Location:1481
      HormR; Domain present in hormone receptors
      pfam00002
      Location:91336
      7tm_2; 7 transmembrane receptor (Secretin family)
    4. NM_001251885.2NP_001238814.1  vasoactive intestinal polypeptide receptor 1 isoform 5

      See identical proteins and their annotated locations for NP_001238814.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal segment in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting isoform (5z) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC092047, AK298115, BU681817
      UniProtKB/TrEMBL
      B4DNY6
      Conserved Domains (2) summary
      smart00008
      Location:32101
      HormR; Domain present in hormone receptors
      pfam00002
      Location:112357
      7tm_2; 7 transmembrane receptor (Secretin family)
    5. NM_004624.4NP_004615.2  vasoactive intestinal polypeptide receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_004615.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC092047, BU681817, DA200439, L13288, X75299
      Consensus CDS
      CCDS2698.1
      UniProtKB/Swiss-Prot
      A5JUT9, B3KPV1, B4DEB5, B4DGI4, F5H1F5, G3V0I1, P32241, Q15871, Q6P2M6
      Related
      ENSP00000327246.4, ENST00000325123.5
      Conserved Domains (2) summary
      smart00008
      Location:59128
      HormR; Domain present in hormone receptors
      pfam00002
      Location:139384
      7tm_2; 7 transmembrane receptor (Secretin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      42489299..42537568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005265437.3XP_005265494.1  vasoactive intestinal polypeptide receptor 1 isoform X1

      Conserved Domains (2) summary
      smart00008
      Location:59128
      HormR; Domain present in hormone receptors
      pfam00002
      Location:138383
      7tm_2; 7 transmembrane receptor (Secretin family)
    2. XM_005265439.3XP_005265496.1  vasoactive intestinal polypeptide receptor 1 isoform X2

      Conserved Domains (2) summary
      smart00008
      Location:1481
      HormR; Domain present in hormone receptors
      pfam00002
      Location:92337
      7tm_2; 7 transmembrane receptor (Secretin family)
    3. XM_011534080.3XP_011532382.1  vasoactive intestinal polypeptide receptor 1 isoform X3

      Conserved Domains (3) summary
      smart00008
      Location:59128
      HormR; Domain present in hormone receptors
      cd14964
      Location:142166
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:139337
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    4. XM_047448850.1XP_047304806.1  vasoactive intestinal polypeptide receptor 1 isoform X4

    5. XM_047448851.1XP_047304807.1  vasoactive intestinal polypeptide receptor 1 isoform X5

    RNA

    1. XR_007095725.1 RNA Sequence

      Related
      ENST00000436487.5
    2. XR_940500.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      42507314..42555561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347745.1XP_054203720.1  vasoactive intestinal polypeptide receptor 1 isoform X1

    2. XM_054347746.1XP_054203721.1  vasoactive intestinal polypeptide receptor 1 isoform X2

    3. XM_054347747.1XP_054203722.1  vasoactive intestinal polypeptide receptor 1 isoform X3

    4. XM_054347748.1XP_054203723.1  vasoactive intestinal polypeptide receptor 1 isoform X4

    5. XM_054347749.1XP_054203724.1  vasoactive intestinal polypeptide receptor 1 isoform X5

    RNA

    1. XR_008486791.1 RNA Sequence

    2. XR_008486792.1 RNA Sequence