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    RGS19 regulator of G protein signaling 19 [ Homo sapiens (human) ]

    Gene ID: 10287, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RGS19provided by HGNC
    Official Full Name
    regulator of G protein signaling 19provided by HGNC
    Primary source
    HGNC:HGNC:13735
    See related
    Ensembl:ENSG00000171700 MIM:605071; AllianceGenome:HGNC:13735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAIP; RGSGAIP
    Summary
    G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 8.6) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RGS19 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (64073181..64079964, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65893259..65900019, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62704534..62711317, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13204 Neighboring gene SOX18 promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62684293-62684982 Neighboring gene SRY-box transcription factor 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62686363-62687052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62687053-62687742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62688433-62689122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62689123-62689810 Neighboring gene transcription elongation factor A2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13207 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62711846-62712019 Neighboring gene microRNA 6813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13209 Neighboring gene opioid related nociceptin receptor 1 Neighboring gene LKAAEAR motif containing 1 Neighboring gene MPRA-validated peak4324 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62723260-62723993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62723994-62724726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62732783-62733284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62738466-62738966 Neighboring gene neuropeptides B and W receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RGS19 activates the MYH9/β-catenin/c-Myc positive feedback loop in hepatocellular carcinoma. Ke S, et al. Exp Mol Med, 2024 Jun. PMID 38825640, Free PMC Article
    2. Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling. de Alba E, et al. J Mol Biol, 1999 Aug 27. PMID 10452897
    3. RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling. Tso PH, et al. Cancer Lett, 2011 Oct 28. PMID 21705135
    4. Clathrin-coated vesicles bearing GAIP possess GTPase-activating protein activity in vitro. Fischer T, et al. Proc Natl Acad Sci U S A, 1999 Jun 8. PMID 10359779, Free PMC Article
    5. Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum. Ip AK, et al. Mol Cell Biochem, 2012 Mar. PMID 22045062

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RGS19 activates the MYH9/beta-catenin/c-Myc positive feedback loop in hepatocellular carcinoma.
      Title: RGS19 activates the MYH9/β-catenin/c-Myc positive feedback loop in hepatocellular carcinoma.
    2. Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer.
      Title: Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer.
    3. RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal.
      Title: RGS19 converts iron deprivation stress into a growth-inhibitory signal.
    4. RGS19 may play an important role in controlling the degree of synergism between FGF-1 receptors and 5-HT1A receptors, that may work together to mediate an anti-depressant effect.
      Title: 5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19.
    5. Overall methylation levels in the promoter regions of three genes (ALDH1A1, OPRL1 and RGS19) are elevated in subjects who were exposed to childhood adversity.
      Title: Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls.
    6. The RGS19 inhibits Ras signaling through a complex network involving a scaffold protein KSR1 and a nucleoside diphosphate kinase Nm23.
      Title: RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras.
    7. elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases
      Title: Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum.
    8. cyclin D1/3 and Cdk6 were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B were reduced
      Title: RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association study of 182 candidate genes in anorexia nervosa.
    10. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in brush border IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 19
    Names
    G alpha interacting protein
    G protein signalling regulator 19
    guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
    regulator of G-protein signalling 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039467.2 → NP_001034556.1  regulator of G-protein signaling 19

      See identical proteins and their annotated locations for NP_001034556.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1.
      Source sequence(s)
      BC001318, BM554550
      Consensus CDS
      CCDS13555.1
      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5
      Related
      ENSP00000333194.5, ENST00000332298.9
      Conserved Domains (1) summary
      cd08745
      Location:87 → 204
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

    2. NM_005873.3 → NP_005864.1  regulator of G-protein signaling 19

      See identical proteins and their annotated locations for NP_005864.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript.
      Source sequence(s)
      AF285097, AL590548, BC063010
      Consensus CDS
      CCDS13555.1
      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5
      Related
      ENSP00000378483.1, ENST00000395042.2
      Conserved Domains (1) summary
      cd08745
      Location:87 → 204
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      64073181..64079964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260183.3 → XP_005260240.1  regulator of G-protein signaling 19 isoform X3

      See identical proteins and their annotated locations for XP_005260240.1

      UniProtKB/TrEMBL
      B4DP94, Q6I9S5
      Conserved Domains (1) summary
      cd08745
      Location:65 → 182
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

    2. XM_047439824.1 → XP_047295780.1  regulator of G-protein signaling 19 isoform X2

      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5

    3. XM_005260182.4 → XP_005260239.1  regulator of G-protein signaling 19 isoform X3

      See identical proteins and their annotated locations for XP_005260239.1

      UniProtKB/TrEMBL
      B4DP94, Q6I9S5
      Conserved Domains (1) summary
      cd08745
      Location:65 → 182
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

    4. XM_011528485.3 → XP_011526787.1  regulator of G-protein signaling 19 isoform X2

      See identical proteins and their annotated locations for XP_011526787.1

      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5
      Conserved Domains (1) summary
      cd08745
      Location:87 → 204
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

    5. XM_011528484.3 → XP_011526786.1  regulator of G-protein signaling 19 isoform X1

      UniProtKB/TrEMBL
      Q6I9S5
      Conserved Domains (1) summary
      cd08745
      Location:116 → 233
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      65893259..65900019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322828.1 → XP_054178803.1  regulator of G-protein signaling 19 isoform X3

      UniProtKB/TrEMBL
      B4DP94, Q6I9S5

    2. XM_054322827.1 → XP_054178802.1  regulator of G-protein signaling 19 isoform X2

      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5

    3. XM_054322826.1 → XP_054178801.1  regulator of G-protein signaling 19 isoform X2

      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5

    4. XM_054322829.1 → XP_054178804.1  regulator of G-protein signaling 19 isoform X3

      UniProtKB/TrEMBL
      B4DP94, Q6I9S5

    5. XM_054322825.1 → XP_054178800.1  regulator of G-protein signaling 19 isoform X1

      UniProtKB/TrEMBL
      Q6I9S5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49795.1 GenPept UniProtKB/Swiss-Prot:P49795

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