TXNDC9 thioredoxin domain containing 9 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TXNDC9provided by HGNC
Official Full Name: thioredoxin domain containing 9provided by HGNC
Primary source: HGNC:HGNC:24110
See related: Ensembl:ENSG00000115514 MIM:612564; AllianceGenome:HGNC:24110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APACD; PHLP3
Summary: The protein encoded by this gene is a member of the thioredoxin family. The exact function of this protein is not known but it is associated with cell differentiation. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thyroid (RPKM 9.5), lymph node (RPKM 9.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q11.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (99306184..99336333, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (99764798..99794965, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (99935445..99952796, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thioredoxin domain-containing protein 9 protects cells against UV-B-provoked apoptosis via NF-kappaB/p65 activation in cutaneous squamous cell carcinoma.
Title: Thioredoxin domain-containing protein 9 protects cells against UV-B-provoked apoptosis via NF-κB/p65 activation in cutaneous squamous cell carcinoma.
TXNDC9 knockdown inhibits lung adenocarcinoma progression by targeting YWHAG.
Title: TXNDC9 knockdown inhibits lung adenocarcinoma progression by targeting YWHAG.
High level of TXNDC9 predicts poor prognosis and contributes to the NF-kappaB-regulated metastatic potential in gastric cancer.
Title: High level of TXNDC9 predicts poor prognosis and contributes to the NF-κB-regulated metastatic potential in gastric cancer.
Thioredoxin domain-containing protein 9 (TXNDC9) contributes to oxaliplatin resistance through regulation of autophagy-apoptosis in colorectal adenocarcinoma.
Title: Thioredoxin domain-containing protein 9 (TXNDC9) contributes to oxaliplatin resistance through regulation of autophagy-apoptosis in colorectal adenocarcinoma.
these studies demonstrate that the TXNDC9-PRDX1 axis plays an important role for ROS to activate AR functions. It provides a proof-of-principle that co-targeting AR and PRDX1 may be more effective to control prostate cancer (PCa) growth.
Title: TXNDC9 regulates oxidative stress-induced androgen receptor signaling to promote prostate cancer progression.
TXNDC9 promotes hepatocellular carcinoma progression by positive regulation of MYC-mediated transcriptional network.
Title: TXNDC9 promotes hepatocellular carcinoma progression by positive regulation of MYC-mediated transcriptional network.
These findings suggest that TXNDC9 gene may function in colorectalcancer development
Title: TXNDC9 expression in colorectal cancer cells and its influence on colorectal cancer prognosis.
PhLP3 is important for the maintenance of beta-tubulin levels in mammalian cells.
Title: Modulation of phosducin-like protein 3 (PhLP3) levels promotes cytoskeletal remodelling in a MAPK and RhoA-dependent manner.
antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo
Title: PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-67500 (e-PCR)
- UniSTS:89229

RH93287 (e-PCR)
- UniSTS:91341

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadherin binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin domain-containing protein 9

Names: ATP binding protein associated with cell differentiation; protein 1-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005783.4 → NP_005774.2 thioredoxin domain-containing protein 9

See identical proteins and their annotated locations for NP_005774.2

Status: REVIEWED

Source sequence(s)

AC079447, BC070183, BG772935

Consensus CDS

CCDS2044.1

UniProtKB/Swiss-Prot

B2R9G8, D3DVI4, O14530, Q53HG4, Q53RV8, Q6NSF5, Q8TB70, Q9BRU6

UniProtKB/TrEMBL

B7Z7A4

Related

ENSP00000264255.3, ENST00000264255.8

Conserved Domains (1) summary

cd02989
Location:68 → 180

Phd_like_TxnDC9; Phosducin (Phd)-like family, Thioredoxin (TRX) domain containing protein 9 (TxnDC9) subfamily; composed of predominantly uncharacterized eukaryotic proteins, containing a TRX-like domain without the redox active CXXC motif. The gene name for the human ...