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    Vwf von Willebrand factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116669, updated on 4-Jan-2025

    Summary

    Official Symbol
    Vwfprovided by RGD
    Official Full Name
    von Willebrand factorprovided by RGD
    Primary source
    RGD:621759
    See related
    EnsemblRapid:ENSRNOG00000019689 AllianceGenome:RGD:621759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including identical protein binding activity; integrin binding activity; and protein-folding chaperone binding activity. Involved in several processes, including cellular response to lipopolysaccharide; liver regeneration; and response to L-ascorbic acid. Located in collagen-containing extracellular matrix and extracellular space. Used to study transient cerebral ischemia. Biomarker of hypertension; mesangial proliferative glomerulonephritis; myocardial infarction; pulmonary fibrosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 693.9), Heart (RPKM 222.5) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Vwf in Genome Data Viewer
    Location:
    4q42
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (160042900..160177757)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (158360152..158491539)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (158085059..158219525)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486684 Neighboring gene CD9 molecule Neighboring gene uncharacterized LOC134486685 Neighboring gene anoctamin 2 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables collagen binding  
    enables collagen binding  
    enables identical protein binding  
    enables identical protein binding  
    enables immunoglobulin binding  
    enables immunoglobulin binding  
    enables integrin binding  
    enables integrin binding  
    enables protease binding  
    enables protease binding  
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of blood coagulation via clotting cascade  
    involved_in blood coagulation  
    acts_upstream_of_or_within blood coagulation  
    involved_in blood coagulation  
    involved_in cell adhesion  
    involved_in cell adhesion  
    involved_in cell-substrate adhesion  
    acts_upstream_of_or_within cell-substrate adhesion  
    involved_in cell-substrate adhesion  
    involved_in cellular response to cold PubMed 
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in extracellular matrix organization  
    acts_upstream_of_or_within hemostasis  
    involved_in hemostasis  
    acts_upstream_of_or_within inflammatory response  
    acts_upstream_of_or_within liver development  
    involved_in liver regeneration PubMed 
    acts_upstream_of_or_within placenta development  
    involved_in platelet activation  
    NOT acts_upstream_of_or_within platelet activation  
    acts_upstream_of_or_within platelet activation  
    involved_in platelet activation  
    involved_in positive regulation of intracellular signal transduction  
    involved_in positive regulation of intracellular signal transduction  
    involved_in response to L-ascorbic acid PubMed 
    involved_in response to X-ray PubMed 
    involved_in response to immobilization stress PubMed 
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in Weibel-Palade body  
    located_in Weibel-Palade body  
    is_active_in collagen-containing extracellular matrix  
    located_in collagen-containing extracellular matrix PubMed 
    located_in collagen-containing extracellular matrix  
    located_in collagen-containing extracellular matrix  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in external side of plasma membrane  
    located_in extracellular region  
    located_in extracellular region  
    located_in extracellular space PubMed 
    located_in extracellular space  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053889.1NP_446341.1  von Willebrand factor precursor

      See identical proteins and their annotated locations for NP_446341.1

      Status: VALIDATED

      Source sequence(s)
      BK007994
      UniProtKB/TrEMBL
      A0A8J8XVZ5, A6ILU6
      Conserved Domains (11) summary
      smart00041
      Location:27262807
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:24312494
      VWC; von Willebrand factor (vWF) type C domain
      smart00216
      Location:377540
      VWD; von Willebrand factor (vWF) type D domain
      smart00327
      Location:12771449
      VWA; von Willebrand factor (vWF) type A domain
      smart00832
      Location:10531127
      C8; This domain contains 8 conserved cysteine residues
      pfam00092
      Location:14981658
      VWA; von Willebrand factor type A domain
      pfam00094
      Location:35179
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:652707
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:21362199
      C8; C8 domain
      pfam16164
      Location:11981276
      VWA_N2; VWA N-terminal
      cl17735
      Location:25812643
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      160042900..160177757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285420.1XP_063141490.1  von Willebrand factor isoform X1

      UniProtKB/TrEMBL
      A0A8J8XVZ5, A6ILU6
      Related
      ENSRNOP00000026643.9, ENSRNOT00000026643.9
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