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    Bean1 brain expressed, associated with Nedd4, 1 [ Mus musculus (house mouse) ]

    Gene ID: 65115, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bean1provided by MGI
    Official Full Name
    brain expressed, associated with Nedd4, 1provided by MGI
    Primary source
    MGI:MGI:1929597
    See related
    Ensembl:ENSMUSG00000031872 AllianceGenome:MGI:1929597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bean
    Summary
    Predicted to be located in membrane. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 31. Orthologous to human BEAN1 (brain expressed associated with NEDD4 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 7.0), testis adult (RPKM 5.9) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bean1 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (104897110..104945730)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104170379..104219098)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53450 Neighboring gene STARR-positive B cell enhancer ABC_E6675 Neighboring gene predicted gene, 29682 Neighboring gene cadherin 5 Neighboring gene STARR-positive B cell enhancer ABC_E8849 Neighboring gene predicted gene 10631 Neighboring gene predicted gene 45750 Neighboring gene STARR-positive B cell enhancer ABC_E9738 Neighboring gene thymidine kinase 2, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Jolliffe CN, et al. Biochem J, 2000 Nov 1. PMID 11042109, Free PMC Article
    2. Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Khang R, et al. Sci Rep, 2021 Nov 23. PMID 34815492, Free PMC Article
    3. Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. Timmermans S, et al. JCI Insight, 2018 Jul 12. PMID 29997285, Free PMC Article
    4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC169808

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein BEAN1
    Names
    brain-expressed protein associating with Nedd4
    protein BEAN

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141922.2 → NP_001135394.1  protein BEAN1 isoform a

      See identical proteins and their annotated locations for NP_001135394.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC115718, AC132390
      Consensus CDS
      CCDS52645.1
      UniProtKB/TrEMBL
      E9PVP2
      Related
      ENSMUSP00000129403.2, ENSMUST00000171018.8

    2. NM_001141924.2 → NP_001135396.1  protein BEAN1 isoform b

      See identical proteins and their annotated locations for NP_001135396.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform b which is shorter than isoform a.
      Source sequence(s)
      AC115718, AC132390
      Consensus CDS
      CCDS52646.1
      UniProtKB/Swiss-Prot
      Q9EQG5
      Related
      ENSMUSP00000090931.6, ENSMUST00000093245.13

    3. NM_001141925.2 → NP_001135397.1  protein BEAN1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks alternate in-frame exons in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform c has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC115718, AC132390
      Consensus CDS
      CCDS52647.1
      UniProtKB/TrEMBL
      E9Q314
      Related
      ENSMUSP00000132056.2, ENSMUST00000164076.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      104897110..104945730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531267.5 → XP_006531330.1  protein BEAN1 isoform X5

      See identical proteins and their annotated locations for XP_006531330.1

      UniProtKB/TrEMBL
      B2RR23

    2. XM_030243708.2 → XP_030099568.1  protein BEAN1 isoform X9

      Related
      ENSMUSP00000148283.2, ENSMUST00000213077.2

    3. XM_006531265.5 → XP_006531328.1  protein BEAN1 isoform X2

    4. XM_006531264.5 → XP_006531327.1  protein BEAN1 isoform X1

      See identical proteins and their annotated locations for XP_006531327.1

      UniProtKB/TrEMBL
      E9PVP2

    5. XM_011248484.4 → XP_011246786.1  protein BEAN1 isoform X7

    6. XM_011248483.3 → XP_011246785.1  protein BEAN1 isoform X6

    7. XM_011248482.3 → XP_011246784.1  protein BEAN1 isoform X4

    8. XM_030243707.2 → XP_030099567.1  protein BEAN1 isoform X8

    9. XM_006531266.4 → XP_006531329.1  protein BEAN1 isoform X3

    10. XM_006531270.1 → XP_006531333.1  protein BEAN1 isoform X9

      See identical proteins and their annotated locations for XP_006531333.1

      UniProtKB/Swiss-Prot
      Q9EQG5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQG5.2 GenPept UniProtKB/Swiss-Prot:Q9EQG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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