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    Zscan5b zinc finger and SCAN domain containing 5B [ Mus musculus (house mouse) ]

    Gene ID: 170734, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zscan5bprovided by MGI
    Official Full Name
    zinc finger and SCAN domain containing 5Bprovided by MGI
    Primary source
    MGI:MGI:2159640
    See related
    Ensembl:ENSMUSG00000058028 AllianceGenome:MGI:2159640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfg1; Zfp371
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; liver; and spleen. Orthologous to several human genes including ZSCAN5A (zinc finger and SCAN domain containing 5A) and ZSCAN5B (zinc finger and SCAN domain containing 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Zscan5b in Genome Data Viewer
    Location:
    7 A1; 7 3.61 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6225277..6242416)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6222278..6239417)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4893 Neighboring gene zinc finger protein 444 Neighboring gene STARR-seq mESC enhancer starr_17966 Neighboring gene galanin-like peptide Neighboring gene STARR-seq mESC enhancer starr_17972 Neighboring gene epididymal protein 13 Neighboring gene STARR-positive B cell enhancer ABC_E11341 Neighboring gene STARR-seq mESC enhancer starr_17975 Neighboring gene STARR-positive B cell enhancer ABC_E4894 Neighboring gene zinc finger protein 667

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis. Ogawa S, et al. Stem Cell Reports, 2019 Jun 11. PMID 31155506, Free PMC Article
    2. NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance. Zhang W, et al. Cell Rep, 2023 Dec 26. PMID 38060382
    3. ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation. Rong Y, et al. Nucleic Acids Res, 2019 Dec 2. PMID 31598710, Free PMC Article
    4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129408, MGC129409

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 5B
    Names
    zinc finger gonad protein 1
    zinc finger protein 371

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133204.2 → NP_573467.2  zinc finger and SCAN domain-containing protein 5B

      See identical proteins and their annotated locations for NP_573467.2

      Status: VALIDATED

      Source sequence(s)
      AK139659, BY725521, CN717865
      Consensus CDS
      CCDS20772.1
      UniProtKB/TrEMBL
      B2RTN3
      Related
      ENSMUSP00000072449.6, ENSMUST00000072662.12
      Conserved Domains (5) summary
      cd07936
      Location:33 → 117
      SCAN; SCAN oligomerization domain
      sd00017
      Location:356 → 376
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:440 → 460
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:438 → 460
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:368 → 393
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6225277..6242416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539573.1 → XP_006539636.1  zinc finger and SCAN domain-containing protein 5B isoform X1

      See identical proteins and their annotated locations for XP_006539636.1

      UniProtKB/TrEMBL
      B2RTN3
      Related
      ENSMUSP00000126044.3, ENSMUST00000165445.3
      Conserved Domains (5) summary
      cd07936
      Location:33 → 117
      SCAN; SCAN oligomerization domain
      sd00017
      Location:356 → 376
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:440 → 460
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:438 → 460
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:368 → 393
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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