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    Slc38a6 solute carrier family 38, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 625098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc38a6provided by MGI
    Official Full Name
    solute carrier family 38, member 6provided by MGI
    Primary source
    MGI:MGI:3648156
    See related
    Ensembl:ENSMUSG00000044712 AllianceGenome:MGI:3648156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG625098
    Summary
    Enables L-glutamate transmembrane transporter activity and L-glutamine transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and glutamine transport. Located in plasma membrane. Is expressed in forelimb long bone. Orthologous to human SLC38A6 (solute carrier family 38 member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 3.8), placenta adult (RPKM 3.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc38a6 in Genome Data Viewer
    Location:
    12 C3; 12 30.42 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (73333622..73408772)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (73286739..73361998)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene menage a trois 1 Neighboring gene STARR-positive B cell enhancer ABC_E7146 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9148 Neighboring gene STARR-seq mESC enhancer starr_32467 Neighboring gene TRM5 tRNA methyltransferase 5 Neighboring gene STARR-seq mESC enhancer starr_32469 Neighboring gene RIKEN cDNA D830013O20 gene Neighboring gene predicted gene, 40442 Neighboring gene predicted gene, 33929

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SLC38A6 expression in macrophages exacerbates pulmonary inflammation. Peng Y, et al. Respir Res, 2023 Jan 27. PMID 36707853, Free PMC Article
    2. Glutamine Uptake via SNAT6 and Caveolin Regulates Glutamine-Glutamate Cycle. Gandasi NR, et al. Int J Mol Sci, 2021 Jan 25. PMID 33503881, Free PMC Article
    3. Histological analysis of SLC38A6 (SNAT6) expression in mouse brain shows selective expression in excitatory neurons with high expression in the synapses. Bagchi S, et al. PLoS One, 2014. PMID 24752331, Free PMC Article
    4. The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38. Sundberg BE, et al. J Mol Neurosci, 2008 Jun. PMID 18418736
    5. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC38A6 expression in macrophages exacerbates pulmonary inflammation.
      Title: SLC38A6 expression in macrophages exacerbates pulmonary inflammation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-glutamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 38 member 6
    Names
    Na(+)-coupled neutral amino acid transporter 6
    amino acid transporter SLC38A6
    probable sodium-coupled neutral amino acid transporter 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037717.3 → NP_001032806.2  solute carrier family 38 member 6

      See identical proteins and their annotated locations for NP_001032806.2

      Status: VALIDATED

      Source sequence(s)
      AC159813
      Consensus CDS
      CCDS49088.1
      UniProtKB/Swiss-Prot
      B2RXN5, G3UVW3
      Related
      ENSMUSP00000120810.2, ENSMUST00000140523.8
      Conserved Domains (2) summary
      COG0814
      Location:45 → 452
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:45 → 452
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      73333622..73408772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244154.4 → XP_011242456.1  solute carrier family 38 member 6 isoform X1

      Conserved Domains (1) summary
      cl00456
      Location:45 → 430
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_036157553.1 → XP_036013446.1  solute carrier family 38 member 6 isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:35 → 365
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_030246831.1 → XP_030102691.1  solute carrier family 38 member 6 isoform X4

      Conserved Domains (1) summary
      cl00456
      Location:1 → 316
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. XM_017315147.2 → XP_017170636.1  solute carrier family 38 member 6 isoform X4

      Conserved Domains (1) summary
      cl00456
      Location:1 → 316
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. XM_036157554.1 → XP_036013447.1  solute carrier family 38 member 6 isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:35 → 365
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    6. XM_006516118.4 → XP_006516181.1  solute carrier family 38 member 6 isoform X2

      Conserved Domains (1) summary
      cl00456
      Location:2 → 397
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    7. XM_030246832.2 → XP_030102692.1  solute carrier family 38 member 6 isoform X5

      Conserved Domains (1) summary
      cl00456
      Location:1 → 283
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. XR_381537.5 RNA Sequence

    2. XR_003950074.2 RNA Sequence

    3. XR_001780471.3 RNA Sequence

    4. XR_001780472.3 RNA Sequence

    5. XR_004937532.1 RNA Sequence

    6. XR_003950073.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3UVW3.1 GenPept UniProtKB/Swiss-Prot:G3UVW3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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