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    Riok2 RIO kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 67045, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Riok2provided by MGI
    Official Full Name
    RIO kinase 2provided by MGI
    Primary source
    MGI:MGI:1914295
    See related
    Ensembl:ENSMUSG00000116564 AllianceGenome:MGI:1914295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010110K24Rik; 2410085M17Rik
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in several processes, including positive regulation of rRNA processing; positive regulation of ribosomal small subunit export from nucleus; and regulation of mitotic metaphase/anaphase transition. Predicted to be located in cytoplasm. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including adrenal gland; eye; genitourinary system; integumental system; and intestine. Orthologous to human RIOK2 (RIO kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.5), bladder adult (RPKM 8.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Riok2 in Genome Data Viewer
    Location:
    17 A3.2; 17 9.77 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (17594594..17615161)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (17374332..17394899)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase antizyme 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3184 Neighboring gene predicted gene, 36768 Neighboring gene STARR-positive B cell enhancer ABC_E7490 Neighboring gene predicted gene, 26873 Neighboring gene STARR-seq mESC enhancer starr_41952 Neighboring gene limb and CNS expressed 1 Neighboring gene STARR-seq mESC enhancer starr_41957 Neighboring gene STARR-seq mESC enhancer starr_41959 Neighboring gene predicted gene, 41537 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia. Messling JE, et al. Blood, 2022 Jan 13. PMID 34359076, Free PMC Article
    2. RIO-kinase 2 is essential for hematopoiesis. Messling JE, et al. PLoS One, 2024. PMID 38564577, Free PMC Article
    3. Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias. Raundhal M, et al. Nat Immunol, 2021 Apr. PMID 33753942, Free PMC Article
    4. The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression. LaRonde-LeBlanc N, et al. Biochim Biophys Acta, 2005 Dec 30. PMID 16182620
    5. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RIO-kinase 2 is essential for hematopoiesis.
      Title: RIO-kinase 2 is essential for hematopoiesis.
    2. Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia.
      Title: Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of SSU-rRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ribosomal small subunit export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ribosomal small subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, small subunit precursor IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, small subunit precursor ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase RIO2
    NP_080210.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025934.2 → NP_080210.1  serine/threonine-protein kinase RIO2

      See identical proteins and their annotated locations for NP_080210.1

      Status: VALIDATED

      Source sequence(s)
      AC154200, AI553565, AK008451, BY133202, BY710172
      Consensus CDS
      CCDS28417.1
      UniProtKB/Swiss-Prot
      Q91XF3, Q9CQS5
      UniProtKB/TrEMBL
      A0A338P7E9
      Related
      ENSMUSP00000024620.7, ENSMUST00000024620.8
      Conserved Domains (3) summary
      COG0478
      Location:8 → 308
      RIO2; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]
      cd05144
      Location:94 → 276
      RIO2_C; C-terminal catalytic domain of the atypical protein serine kinase, RIO2 kinase
      pfam09202
      Location:9 → 91
      Rio2_N; Rio2, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      17594594..17615161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQS5.1 GenPept UniProtKB/Swiss-Prot:Q9CQS5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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