Plet1 placenta expressed transcript 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plet1provided by MGI
Official Full Name: placenta expressed transcript 1provided by MGI
Primary source: MGI:MGI:1923759
See related: Ensembl:ENSMUSG00000032068 AllianceGenome:MGI:1923759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610037B23Rik; 1600029D21Rik
Summary: Involved in negative regulation of cell-matrix adhesion; positive regulation of cell migration; and wound healing, spreading of epidermal cells. Located in apical plasma membrane and external side of plasma membrane. Is expressed in several structures, including branchial arch; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human PLET1 (placenta expressed transcript 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in ovary adult (RPKM 115.4), placenta adult (RPKM 88.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 27.71 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (50405825..50416939)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (50494525..50505639)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia.
Title: Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia.
findings reveal that expression of Plet1 facilitates homeostatic interstitial migration of small intestinal DCs.
Title: Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells.
The endogenous dynamics of Plet1 expression establish important patterning cues within the trophoblast compartment by promoting differentiation towards the syncytiotrophoblast or giant cell pathway in Plet1-low and Plet1-high cells, respectively.
Title: Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation.
these results show that IL-17A-induced PLET1 expression contributes to tissue repair and colon tumorigenesis
Title: IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.
The restricted localization in both differentiated outer root sheath and companion layer cells contacting the hair fiber and epidermal wounds suggests a role for the Plet-1 protein in regulating the interaction of keratinocytes with inert tissues.
Title: Expression of the orphan protein Plet-1 during trichilemmal differentiation of anagen hair follicles.
Plet-1 will thus provide an invaluable tool for genetic analysis of the lineage relationships and molecular mechanisms operating in the development, homeostasis, and injury in several organ/tissue systems
Title: Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

AU043048 (e-PCR)
- UniSTS:159876

1600029D21Rik (e-PCR), detects polymorphism
- UniSTS:502707

RH124650 (e-PCR)
- UniSTS:161472

1600029D21Rik (e-PCR), detects polymorphism
- UniSTS:502739

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of epidermal cells	IBA Inferred from Biological aspect of Ancestor more info
involved_in wound healing, spreading of epidermal cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: placenta-expressed transcript 1 protein

Names: antigen mAgK114

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.