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    Ctdspl CTD small phosphatase like [ Mus musculus (house mouse) ]

    Gene ID: 69274, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctdsplprovided by MGI
    Official Full Name
    CTD small phosphatase likeprovided by MGI
    Primary source
    MGI:MGI:1916524
    See related
    Ensembl:ENSMUSG00000047409 AllianceGenome:MGI:1916524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCP3; HYA22; 2810418J22Rik
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Predicted to be located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human CTDSPL (CTD small phosphatase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 32.1), subcutaneous fat pad adult (RPKM 20.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ctdspl in Genome Data Viewer
    Location:
    9 F3; 9 71.07 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118751313..118873187)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118926536..119044119)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene integrin alpha 9 Neighboring gene uncharacterized LOC102636563 Neighboring gene predicted gene, 51695 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118834312-118834499 Neighboring gene VISTA enhancer mm1627 Neighboring gene STARR-seq mESC enhancer starr_25464 Neighboring gene predicted gene, 53514 Neighboring gene predicted gene, 33645 Neighboring gene microRNA 26a-1 Neighboring gene villin-like Neighboring gene predicted gene, 51697 Neighboring gene phospholipase C, delta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Implication of nanos2-3'UTR in the expression and function of nanos2. Tsuda M, et al. Mech Dev, 2006 Jun. PMID 16806845
    2. MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Zhu Y, et al. Nucleic Acids Res, 2012 May. PMID 22210897, Free PMC Article
    3. Maternal microRNAs are essential for mouse zygotic development. Tang F, et al. Genes Dev, 2007 Mar 15. PMID 17369397, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CTD small phosphatase-like protein
    Names
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
    CTDSP-like
    NIF-like protein
    NLI-interacting factor 1
    carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
    nuclear LIM interactor-interacting factor 1
    small C-terminal domain phosphatase 3
    small CTD phosphatase 3
    NP_598471.3
    XP_006512325.1
    XP_006512326.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133710.3 → NP_598471.3  CTD small phosphatase-like protein

      See identical proteins and their annotated locations for NP_598471.3

      Status: VALIDATED

      Source sequence(s)
      AA239542, AC055818, AC156800, AK013115
      Consensus CDS
      CCDS23605.1
      UniProtKB/Swiss-Prot
      P58465, Q52KL5
      Related
      ENSMUSP00000072852.6, ENSMUST00000073109.12
      Conserved Domains (2) summary
      COG5190
      Location:95 → 270
      FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]
      TIGR02251
      Location:106 → 265
      HIF-SF_euk; Dullard-like phosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      118751313..118873187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512263.2 → XP_006512326.1  CTD small phosphatase-like protein isoform X2

      See identical proteins and their annotated locations for XP_006512326.1

      Conserved Domains (1) summary
      cl21460
      Location:1 → 108
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. XM_006512262.4 → XP_006512325.1  CTD small phosphatase-like protein isoform X1

      UniProtKB/TrEMBL
      G3UXN0
      Related
      ENSMUSP00000133755.2, ENSMUST00000172464.2
      Conserved Domains (1) summary
      TIGR02251
      Location:95 → 254
      HIF-SF_euk; Dullard-like phosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58465.3 GenPept UniProtKB/Swiss-Prot:P58465

    Gene LinkOut

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