Rhod ras homolog family member D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhodprovided by MGI
Official Full Name: ras homolog family member Dprovided by MGI
Primary source: MGI:MGI:108446
See related: Ensembl:ENSMUSG00000041845 AllianceGenome:MGI:108446
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rho; Arhd; RhoM; RhoHP1
Summary: Enables GTP binding activity and protein kinase binding activity. Involved in regulation of actin cytoskeleton organization and regulation of focal adhesion assembly. Acts upstream of or within several processes, including actin filament polymerization; fibroblast growth factor receptor signaling pathway; and protein targeting. Is active in cell projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RHOD (ras homolog family member D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in small intestine adult (RPKM 37.3), duodenum adult (RPKM 29.7) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.07 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4473500..4489562, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4423472..4439534, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RhoD was activated by FGF signaling, and RhoD-activated mDia3C was responsible for the actin filament formation in the protrusion.
Title: RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.
Lysophosphatidic acid signals through LPA2 receptors and Galphaq proteins of cultured proximal tubule cells to transactivate latent TGF-beta in a Rho/Rho-kinase and alphavbeta6 integrin-dependent manner.
Title: Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.
Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments.
Title: Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments.
ERK5 promotes Src-induced podosome formation by inducing RhoGAP7 and thereby limiting Rho activation.
Title: ERK5 promotes Src-induced podosome formation by limiting Rho activation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Arhd (e-PCR), detects polymorphism
- UniSTS:141122

AI326383 (e-PCR)
- UniSTS:181177

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell projection assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to fibroblast growth factor	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to fibroblast growth factor	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho-related GTP-binding protein RhoD

Names: aplysia ras-related homolog D; ras homolog D (RhoD); ras homolog gene family, member D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001329989.1 → NP_001316918.1 rho-related GTP-binding protein RhoD isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC124347, AK008880, BX516716

UniProtKB/TrEMBL

Q545H8
NM_007485.5 → NP_031511.1 rho-related GTP-binding protein RhoD isoform 1

See identical proteins and their annotated locations for NP_031511.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC124347, AK008880, BX516716

Consensus CDS

CCDS29427.1

UniProtKB/Swiss-Prot

O09104, P97348

UniProtKB/TrEMBL

Q545H8

Related

ENSMUSP00000036031.4, ENSMUST00000048197.10

Conserved Domains (2) summary

smart00174
Location:20 → 192

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd04132
Location:17 → 208

Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like