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    Polr1c polymerase (RNA) I polypeptide C [ Mus musculus (house mouse) ]

    Gene ID: 20016, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Polr1cprovided by MGI
    Official Full Name
    polymerase (RNA) I polypeptide Cprovided by MGI
    Primary source
    MGI:MGI:103288
    See related
    Ensembl:ENSMUSG00000067148 AllianceGenome:MGI:103288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    40kDa; RPA40; Polr1e; Rpo1-1
    Summary
    Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase I and transcription by RNA polymerase III. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; genitourinary system; midbrain; respiratory system; and telencephalon. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 45.3), limb E14.5 (RPKM 32.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Polr1c in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46554846..46558971, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46243920..46248045, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene exportin 5 Neighboring gene microRNA 693 Neighboring gene predicted gene, 22474 Neighboring gene STARR-positive B cell enhancer ABC_E11645 Neighboring gene Yip1 domain family, member 3 Neighboring gene leucine rich repeat containing 73

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High conservation of subunit composition of RNA polymerase I(A) between yeast and mouse and the molecular cloning of mouse RNA polymerase I 40-kDa subunit RPA40. Song CZ, et al. J Biol Chem, 1994 Oct 28. PMID 7929437
    2. Isolation and characterization of cDNA encoding mouse RNA polymerase II subunit RPB14. Nishi Y, et al. Gene, 1997 Mar 18. PMID 9099876
    3. Molecular cloning of RPA2, the gene encoding the second largest subunit of mouse RNA polymerase I. Seither P, et al. Genomics, 1996 Oct 1. PMID 8921381
    4. Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development. Falcon KT, et al. Proc Natl Acad Sci U S A, 2022 Aug 2. PMID 35881792, Free PMC Article
    5. Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Campbell GR, et al. Mol Cell Neurosci, 2011 Feb. PMID 21194568, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC161175

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase I activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase III activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerases I and III subunit RPAC1
    Names
    AC40
    DNA-directed RNA polymerase I subunit C
    DNA-directed RNA polymerases I and III 40 kDa polypeptide
    RNA polymerase 1-1 (40 kDa subunit)
    RNA polymerases I and III subunit AC1
    RPC40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009085.2 → NP_033111.2  DNA-directed RNA polymerases I and III subunit RPAC1

      See identical proteins and their annotated locations for NP_033111.2

      Status: VALIDATED

      Source sequence(s)
      AK132114, BY267923, CJ207889
      Consensus CDS
      CCDS37632.1
      UniProtKB/Swiss-Prot
      P52432, Q3UJZ9
      UniProtKB/TrEMBL
      A1L3C2
      Related
      ENSMUSP00000084252.7, ENSMUST00000087026.13
      Conserved Domains (2) summary
      cd07032
      Location:49 → 339
      RNAP_I_II_AC40; AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
      smart00662
      Location:61 → 336
      RPOLD; RNA polymerases D

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46554846..46558971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52432.3 GenPept UniProtKB/Swiss-Prot:P52432

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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