Glrx glutaredoxin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glrxprovided by MGI
Official Full Name: glutaredoxinprovided by MGI
Primary source: MGI:MGI:2135625
See related: Ensembl:ENSMUSG00000021591 AllianceGenome:MGI:2135625
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Grx1; Glrx1; TTase; D13Wsu156e
Summary: Predicted to enable glutathione disulfide oxidoreductase activity and sodium channel regulator activity. Predicted to be involved in positive regulation of membrane potential. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; extraembryonic component; and nervous system. Orthologous to human GLRX (glutaredoxin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 132.0), placenta adult (RPKM 90.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 40.95 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (75988004..75998270)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (75839885..75850151)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m[6] A methylation through upregulation of METTL3 transcription.
Title: NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m(6) A methylation through upregulation of METTL3 transcription.
Macrophage-restricted overexpression of glutaredoxin 1 protects against atherosclerosis by preventing nutrient stress-induced macrophage dysfunction and reprogramming.
Title: Macrophage-restricted overexpression of glutaredoxin 1 protects against atherosclerosis by preventing nutrient stress-induced macrophage dysfunction and reprogramming.
The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function.
Title: The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function.
Glutaredoxin 1 regulates cholesterol metabolism and gallstone formation by influencing protein S-glutathionylation.
Title: Glutaredoxin 1 regulates cholesterol metabolism and gallstone formation by influencing protein S-glutathionylation.
Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1alpha S-glutathionylation during posterior capsular opacification.
Title: Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1α S-glutathionylation during posterior capsular opacification.
Involvement of HIF1 stabilization and VEGF signaling modulated by Grx-1 in murine model of bronchopulmonary dysplasia.
Title: Involvement of HIF1 stabilization and VEGF signaling modulated by Grx-1 in murine model of bronchopulmonary dysplasia.
Glutaredoxin 1 controls monocyte reprogramming during nutrient stress and protects mice against obesity and atherosclerosis in a sex-specific manner.
Title: Glutaredoxin 1 controls monocyte reprogramming during nutrient stress and protects mice against obesity and atherosclerosis in a sex-specific manner.
Glutaredoxin 1 protects neurons from oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3beta/Nrf2 signaling.
Title: Glutaredoxin 1 protects neurons from oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3β/Nrf2 signaling.
Glutaredoxin1 knockout promotes high-fat diet-induced obesity in male mice but not in female ones.
Title: Glutaredoxin1 knockout promotes high-fat diet-induced obesity in male mice but not in female ones.
Oxidized GAPDH transfers S-glutathionylation to a nuclear protein Sirtuin-1 leading to apoptosis.
Title: Oxidized GAPDH transfers S-glutathionylation to a nuclear protein Sirtuin-1 leading to apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124724 (e-PCR)
- UniSTS:161546

C86710 (e-PCR)
- UniSTS:208958

D13Wsu156e (e-PCR), detects polymorphism
- UniSTS:141971

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glutathione disulfide oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione disulfide oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase (glutathione) activity	TAS Traceable Author Statement more info	PubMed
enables sodium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of membrane potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutaredoxin-1

Names: TTase-1; glutaredoxin (thioltransferase); glutaredoxin 1 (thioltransferase); thioltransferase-1

NP_001347080.1

EC 1.8.4.1

NP_444338.2

EC 1.8.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.