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    PTPN12 protein tyrosine phosphatase non-receptor type 12 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 721538, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PTPN12provided by VGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 12provided by VGNC
    Primary source
    VGNC:VGNC:76598
    Locus tag
    EGK_13999
    See related
    Ensembl:ENSMMUG00000009004
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PTPN12 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (128601610..128706518, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (116780884..116887591, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene round spermatid basic protein 1 like Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene histone H3.3-like Neighboring gene beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase-like Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      128601610..128706518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015134193.2 → XP_014989679.1  tyrosine-protein phosphatase non-receptor type 12 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RIQ8, A0A5F8A8K9
      Related
      ENSMMUP00000060202.2, ENSMMUT00000072104.2
      Conserved Domains (2) summary
      smart00194
      Location:28 → 292
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:60 → 292
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. XM_015134192.2 → XP_014989678.1  tyrosine-protein phosphatase non-receptor type 12 isoform X1

      UniProtKB/TrEMBL
      A0A5F8A8K9, F7EGH9
      Related
      ENSMMUP00000011791.3, ENSMMUT00000012577.4
      Conserved Domains (2) summary
      smart00194
      Location:28 → 292
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:60 → 292
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    3. XM_015134195.2 → XP_014989681.1  tyrosine-protein phosphatase non-receptor type 12 isoform X3

      UniProtKB/TrEMBL
      A0A5F8A8K9
      Conserved Domains (2) summary
      cd00047
      Location:1 → 173
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:1 → 173
      Y_phosphatase; Protein-tyrosine phosphatase
    Nucleotide Protein
    Heading Accession and Version

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