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    PLCG2 phospholipase C gamma 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714173, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PLCG2provided by VGNC
    Official Full Name
    phospholipase C gamma 2provided by VGNC
    Primary source
    VGNC:VGNC:76170
    See related
    Ensembl:ENSMMUG00000005334
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PLCG2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 20 NC_041773.1 (68792174..68987061)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 20 NC_027912.1 (66471964..66667439)

    Chromosome 20 - NC_041773.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene c-Maf inducing protein Neighboring gene uncharacterized LOC114674355 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene hydroxysteroid 17-beta dehydrogenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    Names
    phospholipase C, gamma 2 (phosphatidylinositol-specific)
    XP_001111717.2
    XP_028697118.1
    XP_028697119.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041773.1 Reference Mmul_10 Primary Assembly

      Range
      68792174..68987061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001111717.4 → XP_001111717.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1

      UniProtKB/TrEMBL
      F7GH26
      Related
      ENSMMUP00000007058.3, ENSMMUT00000007512.4
      Conserved Domains (10) summary
      cd00275
      Location:1061 → 1187
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08592
      Location:311 → 458
      PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
      cd09932
      Location:641 → 744
      SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
      cd10341
      Location:527 → 627
      SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
      cd11969
      Location:773 → 827
      SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
      cd13234
      Location:840 → 910
      PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
      cd13362
      Location:22 → 140
      PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
      cd16215
      Location:145 → 298
      EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
      cl14615
      Location:926 → 1031
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:475 → 510
      PH-like; Pleckstrin homology-like domain

    2. XM_028841286.1 → XP_028697119.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2

      Conserved Domains (9) summary
      cd00275
      Location:994 → 1120
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08592
      Location:244 → 391
      PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
      cd09932
      Location:574 → 677
      SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
      cd10341
      Location:460 → 560
      SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
      cd11969
      Location:706 → 760
      SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
      cd13234
      Location:773 → 843
      PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
      cd16215
      Location:78 → 231
      EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
      cl14615
      Location:859 → 964
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:1 → 73
      PH-like; Pleckstrin homology-like domain

    3. XM_028841285.1 → XP_028697118.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2

      Conserved Domains (9) summary
      cd00275
      Location:994 → 1120
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08592
      Location:244 → 391
      PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
      cd09932
      Location:574 → 677
      SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
      cd10341
      Location:460 → 560
      SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
      cd11969
      Location:706 → 760
      SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
      cd13234
      Location:773 → 843
      PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
      cd16215
      Location:78 → 231
      EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
      cl14615
      Location:859 → 964
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:1 → 73
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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