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    NOTCH2 notch receptor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 713798, updated on 5-Mar-2024

    Summary

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    Gene symbol
    NOTCH2
    Gene description
    notch receptor 2
    See related
    Ensembl:ENSMMUG00000018375
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NOTCH2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (104176518..104366227)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (121113746..121303387, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene SEC22 homolog B, vesicle trafficking protein Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC114677582 Neighboring gene ADAM metallopeptidase domain 30 Neighboring gene profilin-1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to tumor cell IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurogenic locus notch homolog protein 2
    Names
    Notch homolog 2
    notch 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260662.1 → NP_001247591.1  neurogenic locus notch homolog protein 2 precursor

      See identical proteins and their annotated locations for NP_001247591.1

      Status: PROVISIONAL

      Source sequence(s)
      JU472195
      UniProtKB/TrEMBL
      A0A1D5QEP8, H9YZ83, I0FH75
      Related
      ENSMMUP00000046517.2, ENSMMUT00000068049.2
      Conserved Domains (11) summary
      smart00004
      Location:1418 → 1455
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1879 → 2066
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:182 → 218
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1943 → 1974
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1505 → 1534
      Notch; LNR domain
      pfam03154
      Location:2106 → 2418
      Atrophin-1; Atrophin-1 family
      pfam06816
      Location:1540 → 1594
      NOD; NOTCH protein
      pfam07684
      Location:1619 → 1673
      NODP; NOTCH protein
      pfam11936
      Location:2381 → 2444
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1948 → 2040
      Ank_2; Ankyrin repeats (3 copies)
      cd21703
      Location:1659 → 1740
      JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      104176518..104366227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015147334.2 → XP_015002820.2  neurogenic locus notch homolog protein 2 isoform X1

      UniProtKB/TrEMBL
      F7H1D5
      Related
      ENSMMUP00000024161.4, ENSMMUT00000025824.4
      Conserved Domains (11) summary
      smart00004
      Location:1379 → 1416
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1840 → 2027
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:143 → 179
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1904 → 1935
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1466 → 1495
      Notch; LNR domain
      pfam03154
      Location:2067 → 2379
      Atrophin-1; Atrophin-1 family
      pfam06816
      Location:1501 → 1555
      NOD; NOTCH protein
      pfam07684
      Location:1580 → 1634
      NODP; NOTCH protein
      pfam11936
      Location:2342 → 2405
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1909 → 2001
      Ank_2; Ankyrin repeats (3 copies)
      cd21703
      Location:1620 → 1701
      JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins

    2. XM_015147343.2 → XP_015002829.2  neurogenic locus notch homolog protein 2 isoform X2

      UniProtKB/TrEMBL
      F7DFJ1
      Related
      ENSMMUP00000016684.4, ENSMMUT00000017816.4
      Conserved Domains (1) summary
      cd00054
      Location:182 → 218
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    3. XM_028844860.1 → XP_028700693.1  neurogenic locus notch homolog protein 2 isoform X1

      UniProtKB/TrEMBL
      F7H1D5
      Conserved Domains (11) summary
      smart00004
      Location:1379 → 1416
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1840 → 2027
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:143 → 179
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1904 → 1935
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1466 → 1495
      Notch; LNR domain
      pfam03154
      Location:2067 → 2379
      Atrophin-1; Atrophin-1 family
      pfam06816
      Location:1501 → 1555
      NOD; NOTCH protein
      pfam07684
      Location:1580 → 1634
      NODP; NOTCH protein
      pfam11936
      Location:2342 → 2405
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1909 → 2001
      Ank_2; Ankyrin repeats (3 copies)
      cd21703
      Location:1620 → 1701
      JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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