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    CHRNA2 cholinergic receptor nicotinic alpha 2 subunit [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 712868, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CHRNA2provided by VGNC
    Official Full Name
    cholinergic receptor nicotinic alpha 2 subunitprovided by VGNC
    Primary source
    VGNC:VGNC:71046
    See related
    Ensembl:ENSMMUG00000021514
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    nica2
    Orthologs
    human mouse all
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    Genomic context

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    See CHRNA2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (27727647..27747523, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (27491188..27511274, complement)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 35 Neighboring gene protein tyrosine kinase 2 beta Neighboring gene epoxide hydrolase 2 Neighboring gene clusterin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuronal acetylcholine receptor subunit alpha-2
    Names
    cholinergic receptor, nicotinic, alpha 2 (neuronal)
    nicotinic acetylcholine receptor subunit alpha2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      27727647..27747523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028852489.1 → XP_028708322.1  neuronal acetylcholine receptor subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      G7N0R9
      Conserved Domains (2) summary
      TIGR00860
      Location:58 → 522
      LIC; Cation transporter family protein
      cd19015
      Location:59 → 265
      LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

    2. XM_028852487.1 → XP_028708320.1  neuronal acetylcholine receptor subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      G7N0R9
      Conserved Domains (2) summary
      TIGR00860
      Location:58 → 522
      LIC; Cation transporter family protein
      cd19015
      Location:59 → 265
      LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

    3. XM_028852488.1 → XP_028708321.1  neuronal acetylcholine receptor subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      G7N0R9
      Conserved Domains (2) summary
      TIGR00860
      Location:58 → 522
      LIC; Cation transporter family protein
      cd19015
      Location:59 → 265
      LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

    4. XM_028852486.1 → XP_028708319.1  neuronal acetylcholine receptor subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RBI3, A0A1D5RKW7, F7FFT5, G7N0R9
      Conserved Domains (2) summary
      TIGR00860
      Location:59 → 523
      LIC; Cation transporter family protein
      cd19015
      Location:60 → 266
      LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

    5. XM_015145026.2 → XP_015000512.2  neuronal acetylcholine receptor subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RBI3, A0A1D5RKW7, F7FFT5, G7N0R9
      Related
      ENSMMUP00000028337.4, ENSMMUT00000030282.4
      Conserved Domains (2) summary
      TIGR00860
      Location:59 → 523
      LIC; Cation transporter family protein
      cd19015
      Location:60 → 266
      LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

    6. XM_015145025.2 → XP_015000511.2  neuronal acetylcholine receptor subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RBI3, A0A1D5RKW7, F7FFT5, G7N0R9
      Related
      ENSMMUP00000060961.2, ENSMMUT00000074685.2
      Conserved Domains (2) summary
      TIGR00860
      Location:59 → 523
      LIC; Cation transporter family protein
      cd19015
      Location:60 → 266
      LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

    7. XM_015145024.2 → XP_015000510.2  neuronal acetylcholine receptor subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RBI3, A0A1D5RKW7, F7FFT5, G7N0R9
      Related
      ENSMMUP00000057674.2, ENSMMUT00000064589.2
      Conserved Domains (2) summary
      TIGR00860
      Location:59 → 523
      LIC; Cation transporter family protein
      cd19015
      Location:60 → 266
      LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

    8. XM_028852484.1 → XP_028708317.1  neuronal acetylcholine receptor subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RBI3, A0A1D5RKW7, F7FFT5, G7N0R9
      Conserved Domains (2) summary
      TIGR00860
      Location:59 → 523
      LIC; Cation transporter family protein
      cd19015
      Location:60 → 266
      LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

    9. XM_028852485.1 → XP_028708318.1  neuronal acetylcholine receptor subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RBI3, A0A1D5RKW7, F7FFT5, G7N0R9
      Conserved Domains (2) summary
      TIGR00860
      Location:59 → 523
      LIC; Cation transporter family protein
      cd19015
      Location:60 → 266
      LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

    10. XM_028852483.1 → XP_028708316.1  neuronal acetylcholine receptor subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RBI3, A0A1D5RKW7, F7FFT5, G7N0R9
      Conserved Domains (2) summary
      TIGR00860
      Location:59 → 523
      LIC; Cation transporter family protein
      cd19015
      Location:60 → 266
      LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

    11. XM_028852490.1 → XP_028708323.1  neuronal acetylcholine receptor subunit alpha-2 isoform X3

      Conserved Domains (2) summary
      pfam02932
      Location:113 → 361
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
      cl28912
      Location:1 → 106
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    12. XM_028852491.1 → XP_028708324.1  neuronal acetylcholine receptor subunit alpha-2 isoform X4

      Conserved Domains (2) summary
      pfam02932
      Location:74 → 322
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
      cl28912
      Location:1 → 67
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
    Nucleotide Protein
    Heading Accession and Version

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