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    SMAD2 SMAD family member 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 697581, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SMAD2provided by VGNC
    Official Full Name
    SMAD family member 2provided by VGNC
    Primary source
    VGNC:VGNC:77810
    Locus tag
    EGK_09664
    See related
    Ensembl:ENSMMUG00000007816
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SMAD2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 18 NC_041771.1 (34543595..34640592)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 18 NC_027910.1 (36738986..36835538, complement)

    Chromosome 18 - NC_041771.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 7C Neighboring gene U6 spliceosomal RNA Neighboring gene thymosin beta-10 pseudogene Neighboring gene uncharacterized LOC106994498 Neighboring gene uncharacterized LOC114673768

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mothers against decapentaplegic homolog 2
    Names
    Mothers against decapentaplegic-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266803.1 → NP_001253732.1  mothers against decapentaplegic homolog 2

      See identical proteins and their annotated locations for NP_001253732.1

      Status: PROVISIONAL

      Source sequence(s)
      JV047059
      UniProtKB/TrEMBL
      A0A1D5QCP1, A0A1D5RAI9, A0A8J8Y228, F7CP27, G7MXW5, G7NKP0
      Related
      ENSMMUP00000045810.2, ENSMMUT00000064511.2
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041771.1 Reference Mmul_10 Primary Assembly

      Range
      34543595..34640592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028837695.1 → XP_028693528.1  mothers against decapentaplegic homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QCP1, A0A1D5RAI9, A0A8J8Y228, F7CP27, G7MXW5, G7NKP0
      Related
      ENSMMUP00000010269.2, ENSMMUT00000010947.4
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    2. XM_015121891.2 → XP_014977377.1  mothers against decapentaplegic homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QCP1, A0A1D5RAI9, A0A8J8Y228, F7CP27, G7MXW5, G7NKP0
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    3. XM_028837697.1 → XP_028693530.1  mothers against decapentaplegic homolog 2 isoform X4

      UniProtKB/TrEMBL
      F7CIW0, G7MXW5, H9EM42
      Related
      ENSMMUP00000010270.4, ENSMMUT00000010948.4
      Conserved Domains (2) summary
      cd10491
      Location:8 → 142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236 → 426
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    4. XM_028837698.1 → XP_028693531.1  mothers against decapentaplegic homolog 2 isoform X5

      Conserved Domains (2) summary
      cl00055
      Location:56 → 119
      MH1; N-terminal Mad Homology 1 (MH1) domain
      cl00056
      Location:213 → 374
      MH2; C-terminal Mad Homology 2 (MH2) domain

    5. XM_028837693.1 → XP_028693526.1  mothers against decapentaplegic homolog 2 isoform X1

      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cl00056
      Location:266 → 427
      MH2; C-terminal Mad Homology 2 (MH2) domain

    6. XM_015121890.2 → XP_014977376.1  mothers against decapentaplegic homolog 2 isoform X1

      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cl00056
      Location:266 → 427
      MH2; C-terminal Mad Homology 2 (MH2) domain

    7. XM_015121894.2 → XP_014977380.1  mothers against decapentaplegic homolog 2 isoform X3

      Conserved Domains (2) summary
      cd10491
      Location:8 → 142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cl00056
      Location:236 → 397
      MH2; C-terminal Mad Homology 2 (MH2) domain

    8. XM_015121892.2 → XP_014977378.1  mothers against decapentaplegic homolog 2 isoform X3

      Conserved Domains (2) summary
      cd10491
      Location:8 → 142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cl00056
      Location:236 → 397
      MH2; C-terminal Mad Homology 2 (MH2) domain

    9. XM_015121895.2 → XP_014977381.1  mothers against decapentaplegic homolog 2 isoform X4

      UniProtKB/TrEMBL
      F7CIW0, G7MXW5, H9EM42
      Conserved Domains (2) summary
      cd10491
      Location:8 → 142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236 → 426
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    10. XM_028837696.1 → XP_028693529.1  mothers against decapentaplegic homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QCP1, A0A1D5RAI9, A0A8J8Y228, F7CP27, G7MXW5, G7NKP0
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    11. XM_028837694.1 → XP_028693527.1  mothers against decapentaplegic homolog 2 isoform X1

      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cl00056
      Location:266 → 427
      MH2; C-terminal Mad Homology 2 (MH2) domain
    Nucleotide Protein
    Heading Accession and Version

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