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    ARHGEF1 Rho guanine nucleotide exchange factor 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 722198, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ARHGEF1provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 1provided by VGNC
    Primary source
    VGNC:VGNC:70012
    See related
    Ensembl:ENSMMUG00000022305
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (41026205..41051916)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (37645826..37671539)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19 Neighboring gene CD79a molecule Neighboring gene ETS repressor factor like Neighboring gene Rab acceptor 1 Neighboring gene ATPase Na+/K+ transporting subunit alpha 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 1
    Names
    Rho guanine nucleotide exchange factor (GEF) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      41026205..41051916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028838865.1 → XP_028694698.1  rho guanine nucleotide exchange factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QDZ8, A0A1D5QGD0
      Related
      ENSMMUP00000047100.1, ENSMMUT00000066536.2
      Conserved Domains (4) summary
      cd08755
      Location:52 → 244
      RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
      smart00325
      Location:478 → 662
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03307
      Location:291 → 472
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14679
      Location:696 → 820
      PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    2. XM_015124061.2 → XP_014979547.1  rho guanine nucleotide exchange factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QDZ8, A0A1D5QGD0, A0A5F8A6M7
      Related
      ENSMMUP00000072569.1, ENSMMUT00000101283.1
      Conserved Domains (4) summary
      pfam05887
      Location:315 → 404
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      cd08755
      Location:52 → 244
      RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
      smart00325
      Location:420 → 604
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd14679
      Location:638 → 762
      PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    3. XM_015124063.2 → XP_014979549.1  rho guanine nucleotide exchange factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QDZ8, A0A1D5QGD0, A0A5F8A6M7
      Conserved Domains (4) summary
      pfam05887
      Location:315 → 404
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      cd08755
      Location:52 → 244
      RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
      smart00325
      Location:420 → 604
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd14679
      Location:638 → 762
      PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    Nucleotide Protein
    Heading Accession and Version

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