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    HIF3A hypoxia inducible factor 3 subunit alpha [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 717188, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HIF3Aprovided by VGNC
    Official Full Name
    hypoxia inducible factor 3 subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:73395
    See related
    Ensembl:ENSMMUG00000000215
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HIF3A in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (46323389..46369660)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (41641850..41688064)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene putative elongation factor 1-alpha-like 3 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene IGF like family member 1 Neighboring gene U6 spliceosomal RNA Neighboring gene protein phosphatase 5 catalytic subunit Neighboring gene 60S ribosomal protein L18a-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hypoxia-inducible factor 3-alpha
    Names
    hypoxia inducible factor 3 alpha subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      46323389..46369660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028840261.1 → XP_028696094.1  hypoxia-inducible factor 3-alpha isoform X8

      Conserved Domains (3) summary
      cd00130
      Location:51 → 101
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam11413
      Location:411 → 440
      HIF-1; Hypoxia-inducible factor-1
      pfam14598
      Location:172 → 277
      PAS_11; PAS domain

    2. XM_001108464.4 → XP_001108464.3  hypoxia-inducible factor 3-alpha isoform X6

      UniProtKB/TrEMBL
      G7NN04
      Conserved Domains (5) summary
      cd00083
      Location:13 → 68
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:95 → 170
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam11413
      Location:480 → 509
      HIF-1; Hypoxia-inducible factor-1
      pfam14598
      Location:241 → 346
      PAS_11; PAS domain
      pfam03154
      Location:492 → 600
      Atrophin-1; Atrophin-1 family

    3. XM_028840262.1 → XP_028696095.1  hypoxia-inducible factor 3-alpha isoform X11

      Conserved Domains (2) summary
      cd00130
      Location:51 → 101
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:172 → 277
      PAS_11; PAS domain

    4. XM_028840255.1 → XP_028696088.1  hypoxia-inducible factor 3-alpha isoform X4

      UniProtKB/TrEMBL
      G7NN04
      Conserved Domains (5) summary
      cd00083
      Location:13 → 68
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:95 → 170
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam11413
      Location:480 → 509
      HIF-1; Hypoxia-inducible factor-1
      pfam14598
      Location:241 → 346
      PAS_11; PAS domain
      pfam03154
      Location:492 → 600
      Atrophin-1; Atrophin-1 family

    5. XM_028840259.1 → XP_028696092.1  hypoxia-inducible factor 3-alpha isoform X10

      Conserved Domains (2) summary
      cd00083
      Location:213 → 268
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:295 → 370
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

    6. XM_028840254.1 → XP_028696087.1  hypoxia-inducible factor 3-alpha isoform X1

      Conserved Domains (4) summary
      cd00083
      Location:213 → 268
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:295 → 370
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam11413
      Location:680 → 709
      HIF-1; Hypoxia-inducible factor-1
      pfam14598
      Location:441 → 546
      PAS_11; PAS domain

    7. XM_015124306.2 → XP_014979792.2  hypoxia-inducible factor 3-alpha isoform X3

      Conserved Domains (3) summary
      cd00083
      Location:213 → 268
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:295 → 370
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:441 → 546
      PAS_11; PAS domain

    8. XM_015124305.2 → XP_014979791.2  hypoxia-inducible factor 3-alpha isoform X3

      Conserved Domains (3) summary
      cd00083
      Location:213 → 268
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:295 → 370
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:441 → 546
      PAS_11; PAS domain

    9. XM_015124303.2 → XP_014979789.2  hypoxia-inducible factor 3-alpha isoform X2

      UniProtKB/TrEMBL
      F6XI35
      Related
      ENSMMUP00000000306.4, ENSMMUT00000000325.4
      Conserved Domains (4) summary
      cd00083
      Location:213 → 268
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:295 → 370
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam11413
      Location:680 → 709
      HIF-1; Hypoxia-inducible factor-1
      pfam14598
      Location:441 → 546
      PAS_11; PAS domain

    10. XM_028840260.1 → XP_028696093.1  hypoxia-inducible factor 3-alpha isoform X8

      Conserved Domains (3) summary
      cd00130
      Location:51 → 101
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam11413
      Location:411 → 440
      HIF-1; Hypoxia-inducible factor-1
      pfam14598
      Location:172 → 277
      PAS_11; PAS domain

    11. XM_015124307.2 → XP_014979793.2  hypoxia-inducible factor 3-alpha isoform X9

      UniProtKB/TrEMBL
      F6XI56, G7NN04
      Related
      ENSMMUP00000000304.4, ENSMMUT00000000322.4
      Conserved Domains (3) summary
      cd00130
      Location:51 → 101
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam11413
      Location:411 → 440
      HIF-1; Hypoxia-inducible factor-1
      pfam14598
      Location:172 → 277
      PAS_11; PAS domain

    12. XM_028840256.1 → XP_028696089.1  hypoxia-inducible factor 3-alpha isoform X5

      UniProtKB/TrEMBL
      G7NN04
      Conserved Domains (6) summary
      cd00083
      Location:11 → 66
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:93 → 168
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam11413
      Location:478 → 507
      HIF-1; Hypoxia-inducible factor-1
      pfam14598
      Location:239 → 344
      PAS_11; PAS domain
      pfam16014
      Location:361 → 523
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
      pfam03154
      Location:490 → 598
      Atrophin-1; Atrophin-1 family

    13. XM_028840258.1 → XP_028696091.1  hypoxia-inducible factor 3-alpha isoform X8

      Conserved Domains (3) summary
      cd00130
      Location:51 → 101
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam11413
      Location:411 → 440
      HIF-1; Hypoxia-inducible factor-1
      pfam14598
      Location:172 → 277
      PAS_11; PAS domain

    14. XM_002801303.3 → XP_002801349.2  hypoxia-inducible factor 3-alpha isoform X7

      UniProtKB/TrEMBL
      F6XI77, G7NN04
      Related
      ENSMMUP00000000303.4, ENSMMUT00000000321.4
      Conserved Domains (5) summary
      cd00083
      Location:11 → 66
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:93 → 168
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam11413
      Location:478 → 507
      HIF-1; Hypoxia-inducible factor-1
      pfam14598
      Location:239 → 344
      PAS_11; PAS domain
      pfam03154
      Location:490 → 598
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein
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