CHEK2 checkpoint kinase 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: CHEK2provided by VGNC
Official Full Name: checkpoint kinase 2provided by VGNC
Primary source: VGNC:VGNC:70958
See related: Ensembl:ENSMMUG00000020486
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	10	NC_041763.1 (22804832..22859276)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	10	NC_027902.1 (70542885..70597383, complement)

Chromosome 10 - NC_041763.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

PMC111029P10 (e-PCR)
- UniSTS:270203

PMC111029P11 (e-PCR)
- UniSTS:270204

PMC111029P12 (e-PCR)
- UniSTS:270205

PMC111029P2 (e-PCR)
- UniSTS:270208

PMC111029P7 (e-PCR)
- UniSTS:270213

PMC111029P8 (e-PCR)
- UniSTS:270214

PMC111029P9 (e-PCR)
- UniSTS:270215

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase Chk2

Names: CHK2 checkpoint homolog

XP_015005469.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041763.1 Reference Mmul_10 Primary Assembly

Range

22804832..22859276

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015149983.2 → XP_015005469.1 serine/threonine-protein kinase Chk2

UniProtKB/TrEMBL

F6SZM3, F6VJA7, G7N3I1

Related

ENSMMUP00000026981.4, ENSMMUT00000028833.4

Conserved Domains (2) summary

cd00060
Location:93 → 201

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd14084
Location:213 → 486

STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2