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    DOCK8 dedicator of cytokinesis 8 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 698081, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DOCK8provided by VGNC
    Official Full Name
    dedicator of cytokinesis 8provided by VGNC
    Primary source
    VGNC:VGNC:71865
    See related
    Ensembl:ENSMMUG00000016976
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DOCK8 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (83396629..83636142, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (84096566..84383020, complement)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene uncharacterized LOC114672806 Neighboring gene V-type proton ATPase subunit D pseudogene Neighboring gene Zn regulated GTPase metalloprotein activator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of establishment of T cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell leading edge IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 8
    Names
    dedicator of cytokinesis protein 8-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      83396629..83636142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015117845.2 → XP_014973331.2  dedicator of cytokinesis protein 8 isoform X1

      UniProtKB/TrEMBL
      G7NG93
      Related
      ENSMMUP00000079412.1, ENSMMUT00000092827.1
      Conserved Domains (3) summary
      cd08696
      Location:559 → 739
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11701
      Location:1635 → 2056
      DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
      pfam11878
      Location:73 → 164
      DUF3398; Domain of unknown function (DUF3398)

    2. XM_028835223.1 → XP_028691056.1  dedicator of cytokinesis protein 8 isoform X3

      UniProtKB/TrEMBL
      F7AZW3, F7BL55, G7NG93
      Conserved Domains (3) summary
      cd08696
      Location:491 → 671
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11701
      Location:1567 → 1988
      DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
      pfam11878
      Location:5 → 96
      DUF3398; Domain of unknown function (DUF3398)

    3. XM_015117843.2 → XP_014973329.2  dedicator of cytokinesis protein 8 isoform X3

      UniProtKB/TrEMBL
      F7AZW3, F7BL55, G7NG93
      Related
      ENSMMUP00000022330.4, ENSMMUT00000023857.4
      Conserved Domains (3) summary
      cd08696
      Location:491 → 671
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11701
      Location:1567 → 1988
      DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
      pfam11878
      Location:5 → 96
      DUF3398; Domain of unknown function (DUF3398)

    4. XM_028835224.1 → XP_028691057.1  dedicator of cytokinesis protein 8 isoform X3

      UniProtKB/TrEMBL
      F7AZW3, F7BL55, G7NG93
      Conserved Domains (3) summary
      cd08696
      Location:491 → 671
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11701
      Location:1567 → 1988
      DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
      pfam11878
      Location:5 → 96
      DUF3398; Domain of unknown function (DUF3398)

    5. XM_015117848.2 → XP_014973334.2  dedicator of cytokinesis protein 8 isoform X3

      UniProtKB/TrEMBL
      F7AZW3, F7BL55, G7NG93
      Conserved Domains (3) summary
      cd08696
      Location:491 → 671
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11701
      Location:1567 → 1988
      DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
      pfam11878
      Location:5 → 96
      DUF3398; Domain of unknown function (DUF3398)

    6. XM_015117846.2 → XP_014973332.2  dedicator of cytokinesis protein 8 isoform X2

      UniProtKB/TrEMBL
      F7BKY8, G7NG93
      Related
      ENSMMUP00000039150.3, ENSMMUT00000046106.3
      Conserved Domains (3) summary
      cd08696
      Location:543 → 723
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11701
      Location:1619 → 2040
      DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
      pfam11878
      Location:57 → 148
      DUF3398; Domain of unknown function (DUF3398)

    7. XM_015117850.2 → XP_014973336.2  dedicator of cytokinesis protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A5F8AQR5
      Related
      ENSMMUP00000059016.2, ENSMMUT00000063350.2
      Conserved Domains (3) summary
      cd08696
      Location:491 → 671
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11701
      Location:1535 → 1956
      DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
      pfam11878
      Location:5 → 96
      DUF3398; Domain of unknown function (DUF3398)

    8. XM_015117849.2 → XP_014973335.2  dedicator of cytokinesis protein 8 isoform X3

      UniProtKB/TrEMBL
      F7AZW3, F7BL55, G7NG93
      Related
      ENSMMUP00000039148.3, ENSMMUT00000046104.3
      Conserved Domains (3) summary
      cd08696
      Location:491 → 671
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11701
      Location:1567 → 1988
      DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
      pfam11878
      Location:5 → 96
      DUF3398; Domain of unknown function (DUF3398)
    Nucleotide Protein
    Heading Accession and Version

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