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    ESR2 estrogen receptor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574110, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ESR2provided by VGNC
    Official Full Name
    estrogen receptor 2provided by VGNC
    Primary source
    VGNC:VGNC:72433
    Locus tag
    EGK_18278
    See related
    Ensembl:ENSMMUG00000022839
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ESR2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (126306692..126375132, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (126183143..126254775, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 subunit 2 pseudogene Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene U6 spliceosomal RNA Neighboring gene translationally-controlled tumor protein pseudogene Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Neighboring gene A-kinase anchoring protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Estrogen-induced retinal endothelial cell proliferation: possible involvement of pigment epithelium-derived factor and phosphoinositide 3-kinase/mitogen-activated protein kinase pathways. Parvathaneni K, et al. J Ocul Pharmacol Ther, 2013 Feb. PMID 23046437, Free PMC Article
    2. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. an 17b-estradiol-induced increase in the proliferation of rhesus retinal capillary endothelial cells may be mediated by the action of ERb.
      Title: Estrogen-induced retinal endothelial cell proliferation: possible involvement of pigment epithelium-derived factor and phosphoinositide 3-kinase/mitogen-activated protein kinase pathways.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear estrogen receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    estrogen receptor beta
    Names
    ER-beta
    nuclear receptor subfamily 3 group A member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001265821.2 → NP_001252750.1  estrogen receptor beta

      See identical proteins and their annotated locations for NP_001252750.1

      Status: PROVISIONAL

      Source sequence(s)
      JV636022
      UniProtKB/TrEMBL
      A0A8J8Y110, F6UFZ0, G7MYA0, I2CWM7
      Related
      ENSMMUP00000030076.4, ENSMMUT00000032147.4
      Conserved Domains (3) summary
      cd06949
      Location:263 → 498
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:144 → 225
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:16 → 122
      ERbeta_N; Estrogen receptor beta

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      126306692..126375132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015143836.2 → XP_014999322.2  estrogen receptor beta isoform X1

      UniProtKB/TrEMBL
      F6UFU5, F6UFZ0
      Related
      ENSMMUP00000030079.3, ENSMMUT00000032150.4
      Conserved Domains (3) summary
      cd06949
      Location:263 → 475
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:144 → 225
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:16 → 122
      ERbeta_N; Estrogen receptor beta
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TTE5.1 GenPept UniProtKB/Swiss-Prot:Q9TTE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials