CGAS cyclic GMP-AMP synthase [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: CGASprovided by VGNC
Official Full Name: cyclic GMP-AMP synthaseprovided by VGNC
Primary source: VGNC:VGNC:71069
See related: Ensembl:ENSMMUG00000019606
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: MB21D1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	4	NC_041757.1 (99487487..99516865)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	4	NC_027896.1 (71440109..71469321, complement)

Chromosome 4 - NC_041757.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

REN32836 (e-PCR)
- UniSTS:357636

REN32838 (e-PCR)
- UniSTS:357638

REN32842 (e-PCR)
- UniSTS:357642

REN32846 (e-PCR)
- UniSTS:357646

REN32847 (e-PCR)
- UniSTS:357647

ECD08506 (e-PCR)
- UniSTS:289554

REN32852 (e-PCR)
- UniSTS:357652

ECD22921 (e-PCR)
- UniSTS:303906

ECD14968 (e-PCR)
- UniSTS:295985

ECD19638 (e-PCR)
- UniSTS:300643

stSG625893 (e-PCR)
- UniSTS:457060

stSG625897 (e-PCR)
- UniSTS:457064

stSG625898 (e-PCR)
- UniSTS:457065

stSG625899 (e-PCR)
- UniSTS:457066

stSG625901 (e-PCR)
- UniSTS:457068

stSG625903 (e-PCR)
- UniSTS:457070

stSG625904 (e-PCR)
- UniSTS:457071

stSG625905 (e-PCR)
- UniSTS:457072

ECD11966 (e-PCR)
- UniSTS:292999

REN32774 (e-PCR)
- UniSTS:357574

REN32775 (e-PCR)
- UniSTS:357575

REN32778 (e-PCR)
- UniSTS:357578

REN32784 (e-PCR)
- UniSTS:357584

REN32785 (e-PCR)
- UniSTS:357585

REN32787 (e-PCR)
- UniSTS:357587

REN32791 (e-PCR)
- UniSTS:357591

REN32792 (e-PCR)
- UniSTS:357592

REN32794 (e-PCR)
- UniSTS:357594

REN32800 (e-PCR)
- UniSTS:357600

REN32802 (e-PCR)
- UniSTS:357602

REN32805 (e-PCR)
- UniSTS:357605

REN32806 (e-PCR)
- UniSTS:357606

REN32807 (e-PCR)
- UniSTS:357607

REN32817 (e-PCR)
- UniSTS:357617

REN32818 (e-PCR)
- UniSTS:357618

REN32824 (e-PCR)
- UniSTS:357624

REN32829 (e-PCR)
- UniSTS:357629

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 2',3'-cyclic GMP-AMP synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to exogenous dsRNA	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in paracrine signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of defense response to virus by host	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of type I interferon production	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cyclic GMP-AMP synthase

Names: Mab-21 domain containing 1

NP_001305104.1

EC 2.7.7.86

XP_001109400.2

EC 2.7.7.86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318175.1 → NP_001305104.1 cyclic GMP-AMP synthase

Status: PROVISIONAL

Source sequence(s)

KR062011

UniProtKB/TrEMBL

A0A0F7J4C8, F7B8L6

Conserved Domains (1) summary

pfam03281
Location:214 → 514

Mab-21; Mab-21 protein