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    IL15 interleukin 15 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 699616, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IL15provided by VGNC
    Official Full Name
    interleukin 15provided by VGNC
    Primary source
    VGNC:VGNC:73710
    See related
    Ensembl:ENSMMUG00000019092
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    IL-15
    Orthologs
    human mouse all
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    Genomic context

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    See IL15 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (139514695..139613055)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (141699343..141797318)

    Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene probable ribosome biogenesis protein RLP24 pseudogene Neighboring gene inositol polyphosphate-4-phosphatase type II B Neighboring gene uncharacterized LOC114678406 Neighboring gene 60S ribosomal protein L21 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytomegalovirus mediates expansion of IL-15-responsive innate-memory cells with SIV killing function. Méndez-Lagares G, et al. J Clin Invest, 2021 Aug 2. PMID 34153005, Free PMC Article
    2. IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. Picker LJ, et al. J Clin Invest, 2006 Jun. PMID 16691294, Free PMC Article
    3. Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates. Lugli E, et al. Blood, 2010 Oct 28. PMID 20631381, Free PMC Article
    4. Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection. Eberly MD, et al. J Immunol, 2009 Feb 1. PMID 19155491, Free PMC Article
    5. Comparative sequence analysis of cytokine genes from human and nonhuman primates. Villinger F, et al. J Immunol, 1995 Oct 15. PMID 7561102

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cytomegalovirus mediates expansion of IL-15-responsive innate-memory cells with SIV killing function.
      Title: Cytomegalovirus mediates expansion of IL-15-responsive innate-memory cells with SIV killing function.
    2. IL 15 generates a dramatic expansion of short-lived memory CD8 T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4(+) and CD8(+) T cells.
      Title: Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates.
    3. IL-15 secretion significantly correlates with the up-regulated expression of CD4 on memory CD4 T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
      Title: Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection.
    4. These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 + T cell compartment.
      Title: IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neutrophil activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044731.1 → NP_001038196.1  interleukin-15 precursor

      See identical proteins and their annotated locations for NP_001038196.1

      Status: PROVISIONAL

      Source sequence(s)
      U19843
      UniProtKB/Swiss-Prot
      P48092
      UniProtKB/TrEMBL
      F6TFU5
      Related
      ENSMMUP00000025100.3, ENSMMUT00000026825.4
      Conserved Domains (1) summary
      pfam02372
      Location:33 → 154
      IL15; Interleukin 15

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041758.1 Reference Mmul_10 Primary Assembly

      Range
      139514695..139613055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015139228.2 → XP_014994714.1  interleukin-15 isoform X1

      UniProtKB/Swiss-Prot
      P48092
      UniProtKB/TrEMBL
      F6TFU5
      Conserved Domains (1) summary
      pfam02372
      Location:33 → 154
      IL15; Interleukin 15

    2. XM_015139230.2 → XP_014994716.1  interleukin-15 isoform X3

      UniProtKB/TrEMBL
      G7MS16
      Conserved Domains (1) summary
      pfam02372
      Location:10 → 127
      IL15; Interleukin 15

    3. XM_015139229.2 → XP_014994715.1  interleukin-15 isoform X1

      UniProtKB/Swiss-Prot
      P48092
      UniProtKB/TrEMBL
      F6TFU5
      Conserved Domains (1) summary
      pfam02372
      Location:33 → 154
      IL15; Interleukin 15

    4. XM_028848015.1 → XP_028703848.1  interleukin-15 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48092.1 GenPept UniProtKB/Swiss-Prot:P48092

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials