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    FGFR2 fibroblast growth factor receptor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 715949, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FGFR2provided by VGNC
    Official Full Name
    fibroblast growth factor receptor 2provided by VGNC
    Primary source
    VGNC:VGNC:72652
    Locus tag
    EGK_20127
    See related
    Ensembl:ENSMMUG00000009594
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See FGFR2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 9 NC_041762.1 (121951371..122073604, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 9 NC_027901.1 (117482017..117605565, complement)

    Chromosome 9 - NC_041762.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114670052 Neighboring gene 60S ribosomal protein L19 pseudogene Neighboring gene uncharacterized LOC114670053 Neighboring gene uncharacterized LOC107000305 Neighboring gene uncharacterized LOC114670054

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor receptor 2
    Names
    fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041762.1 Reference Mmul_10 Primary Assembly

      Range
      121951371..122073604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015148337.2 → XP_015003823.1  fibroblast growth factor receptor 2 isoform X13

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (4) summary
      cd05101
      Location:358 → 670
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:275 → 305
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd05857
      Location:58 → 152
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cd05858
      Location:160 → 264
      IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

    2. XM_015148336.2 → XP_015003822.1  fibroblast growth factor receptor 2 isoform X12

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (4) summary
      cd05101
      Location:360 → 672
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:275 → 305
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd05857
      Location:58 → 152
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cd05858
      Location:160 → 264
      IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

    3. XM_015148335.2 → XP_015003821.1  fibroblast growth factor receptor 2 isoform X11

      UniProtKB/TrEMBL
      F7A5X3, H9FRD6
      Related
      ENSMMUP00000012567.4, ENSMMUT00000013412.4
      Conserved Domains (5) summary
      cd05101
      Location:361 → 673
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:276 → 306
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:160 → 163
      Ig; Ig strand A [structural motif]
      cd05857
      Location:58 → 152
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:160 → 262
      Ig; Immunoglobulin domain

    4. XM_028826933.1 → XP_028682766.1  fibroblast growth factor receptor 2 isoform X9

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (4) summary
      cd05101
      Location:384 → 696
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:301 → 331
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd05857
      Location:84 → 178
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cd05858
      Location:186 → 290
      IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

    5. XM_015148334.2 → XP_015003820.1  fibroblast growth factor receptor 2 isoform X7

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (4) summary
      cd05101
      Location:386 → 698
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:301 → 331
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd05857
      Location:84 → 178
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cd05858
      Location:186 → 290
      IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

    6. XM_028826932.1 → XP_028682765.1  fibroblast growth factor receptor 2 isoform X8

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (5) summary
      cd05101
      Location:385 → 697
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:302 → 332
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:186 → 189
      Ig; Ig strand A [structural motif]
      cd05857
      Location:84 → 178
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:186 → 288
      Ig; Immunoglobulin domain

    7. XM_015148333.2 → XP_015003819.1  fibroblast growth factor receptor 2 isoform X6

      UniProtKB/TrEMBL
      A0A1D5QFH7, H9FRD6
      Conserved Domains (5) summary
      cd05101
      Location:387 → 699
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:302 → 332
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:186 → 189
      Ig; Ig strand A [structural motif]
      cd05857
      Location:84 → 178
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:186 → 288
      Ig; Immunoglobulin domain

    8. XM_015148330.2 → XP_015003816.1  fibroblast growth factor receptor 2 isoform X4

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (5) summary
      cd05101
      Location:473 → 785
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:390 → 420
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd04973
      Location:50 → 143
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cd05858
      Location:275 → 379
      IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

    9. XM_015148328.2 → XP_015003814.1  fibroblast growth factor receptor 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QYN7, H9FRD6
      Related
      ENSMMUP00000053169.1, ENSMMUT00000060476.2
      Conserved Domains (5) summary
      cd05101
      Location:475 → 787
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:390 → 420
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd04973
      Location:50 → 143
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cd05858
      Location:275 → 379
      IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

    10. XM_015148329.2 → XP_015003815.1  fibroblast growth factor receptor 2 isoform X3

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (6) summary
      cd05101
      Location:474 → 786
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:391 → 421
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:275 → 278
      Ig; Ig strand A [structural motif]
      cd04973
      Location:50 → 143
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:275 → 377
      Ig; Immunoglobulin domain

    11. XM_015148327.2 → XP_015003813.1  fibroblast growth factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QJG1, A0A5S6R976, A0A8J8Y1Y1, G7N1A1, H9FRD6
      Conserved Domains (6) summary
      cd05101
      Location:476 → 788
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:391 → 421
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:275 → 278
      Ig; Ig strand A [structural motif]
      cd04973
      Location:50 → 143
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:275 → 377
      Ig; Immunoglobulin domain

    12. XM_015148331.2 → XP_015003817.1  fibroblast growth factor receptor 2 isoform X5

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (6) summary
      cd05101
      Location:476 → 788
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:391 → 421
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:275 → 278
      Ig; Ig strand A [structural motif]
      cd04973
      Location:50 → 143
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:275 → 377
      Ig; Immunoglobulin domain

    13. XM_028826937.1 → XP_028682770.1  fibroblast growth factor receptor 2 isoform X9

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (4) summary
      cd05101
      Location:384 → 696
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:301 → 331
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd05857
      Location:84 → 178
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cd05858
      Location:186 → 290
      IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

    14. XM_028826935.1 → XP_028682768.1  fibroblast growth factor receptor 2 isoform X8

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (5) summary
      cd05101
      Location:385 → 697
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:302 → 332
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:186 → 189
      Ig; Ig strand A [structural motif]
      cd05857
      Location:84 → 178
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:186 → 288
      Ig; Immunoglobulin domain

    15. XM_028826931.1 → XP_028682764.1  fibroblast growth factor receptor 2 isoform X6

      UniProtKB/TrEMBL
      A0A1D5QFH7, H9FRD6
      Related
      ENSMMUP00000046797.2, ENSMMUT00000064110.2
      Conserved Domains (5) summary
      cd05101
      Location:387 → 699
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:302 → 332
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:186 → 189
      Ig; Ig strand A [structural motif]
      cd05857
      Location:84 → 178
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:186 → 288
      Ig; Immunoglobulin domain

    16. XM_028826926.1 → XP_028682759.1  fibroblast growth factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QJG1, A0A5S6R976, A0A8J8Y1Y1, G7N1A1, H9FRD6
      Conserved Domains (6) summary
      cd05101
      Location:476 → 788
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:391 → 421
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:275 → 278
      Ig; Ig strand A [structural motif]
      cd04973
      Location:50 → 143
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:275 → 377
      Ig; Immunoglobulin domain

    17. XM_028826927.1 → XP_028682760.1  fibroblast growth factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QJG1, A0A5S6R976, A0A8J8Y1Y1, G7N1A1, H9FRD6
      Conserved Domains (6) summary
      cd05101
      Location:476 → 788
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:391 → 421
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:275 → 278
      Ig; Ig strand A [structural motif]
      cd04973
      Location:50 → 143
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:275 → 377
      Ig; Immunoglobulin domain

    18. XM_028826928.1 → XP_028682761.1  fibroblast growth factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QJG1, A0A5S6R976, A0A8J8Y1Y1, G7N1A1, H9FRD6
      Related
      ENSMMUP00000048184.2, ENSMMUT00000076005.2
      Conserved Domains (6) summary
      cd05101
      Location:476 → 788
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:391 → 421
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:275 → 278
      Ig; Ig strand A [structural motif]
      cd04973
      Location:50 → 143
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:275 → 377
      Ig; Immunoglobulin domain

    19. XM_028826930.1 → XP_028682763.1  fibroblast growth factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QJG1, A0A5S6R976, A0A8J8Y1Y1, G7N1A1, H9FRD6
      Conserved Domains (6) summary
      cd05101
      Location:476 → 788
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:391 → 421
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:275 → 278
      Ig; Ig strand A [structural motif]
      cd04973
      Location:50 → 143
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:275 → 377
      Ig; Immunoglobulin domain

    20. XM_028826939.1 → XP_028682772.1  fibroblast growth factor receptor 2 isoform X14

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (3) summary
      cd05857
      Location:44 → 128
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05101
      Location:337 → 649
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      cl11960
      Location:151 → 238
      Ig; Immunoglobulin domain

    21. XM_028826936.1 → XP_028682769.1  fibroblast growth factor receptor 2 isoform X10

      UniProtKB/TrEMBL
      H9FRD6
      Conserved Domains (3) summary
      cd05857
      Location:73 → 157
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05101
      Location:366 → 678
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      cl11960
      Location:180 → 267
      Ig; Immunoglobulin domain
    Nucleotide Protein
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