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    ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 705403, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ACAP2provided by VGNC
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 2provided by VGNC
    Primary source
    VGNC:VGNC:69428
    See related
    Ensembl:ENSMMUG00000013092
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    CENTB2
    Orthologs
    human mouse all
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    Genomic context

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    See ACAP2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (2509297..2688565)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (202095311..202274908, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene U6atac minor spliceosomal RNA Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 2 Neighboring gene xyloside xylosyltransferase 1 Neighboring gene transcription and mRNA export factor ENY2 pseudogene Neighboring gene uncharacterized LOC106997193

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
    Names
    centaurin, beta 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261274.1 → NP_001248203.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

      See identical proteins and their annotated locations for NP_001248203.1

      Status: PROVISIONAL

      Source sequence(s)
      JU474967
      UniProtKB/TrEMBL
      G7MKG1, H9EUG8
      Related
      ENSMMUP00000078234.1, ENSMMUT00000099379.1
      Conserved Domains (5) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      smart00105
      Location:402 → 517
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:610 → 726
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:269 → 365
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:638 → 671
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      2509297..2688565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015132484.2 → XP_014987970.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5R5D3
      Related
      ENSMMUP00000056810.2, ENSMMUT00000058657.2
      Conserved Domains (7) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      smart00105
      Location:413 → 528
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:656 → 772
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:273 → 376
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:271 → 372
      PH; PH domain
      pfam12796
      Location:656 → 750
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:684 → 717
      ANK; ANK repeat [structural motif]

    2. XM_015132489.2 → XP_014987975.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      G7MKG1
      Conserved Domains (7) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      smart00105
      Location:413 → 528
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:621 → 737
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:273 → 376
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:271 → 372
      PH; PH domain
      pfam12796
      Location:621 → 715
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:649 → 682
      ANK; ANK repeat [structural motif]

    3. XM_015132487.2 → XP_014987973.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A1D5R5D3
      Conserved Domains (5) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      smart00105
      Location:406 → 521
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:649 → 765
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:273 → 369
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:677 → 710
      ANK; ANK repeat [structural motif]

    4. XM_015132486.2 → XP_014987972.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5R5D3
      Conserved Domains (7) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      smart00105
      Location:409 → 524
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:652 → 768
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:269 → 372
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 368
      PH; PH domain
      pfam12796
      Location:652 → 746
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:680 → 713
      ANK; ANK repeat [structural motif]

    5. XM_015132490.2 → XP_014987976.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A5F8AU18, G7MKG1
      Related
      ENSMMUP00000080426.1, ENSMMUT00000099702.1
      Conserved Domains (7) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      smart00105
      Location:409 → 524
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:617 → 733
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:269 → 372
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 368
      PH; PH domain
      pfam12796
      Location:617 → 711
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:645 → 678
      ANK; ANK repeat [structural motif]

    6. XM_015132488.2 → XP_014987974.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A1D5R5D3
      Conserved Domains (7) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      smart00105
      Location:402 → 517
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:645 → 761
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:269 → 365
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 361
      PH; PH domain
      pfam12796
      Location:645 → 739
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:673 → 706
      ANK; ANK repeat [structural motif]

    7. XM_015132491.2 → XP_014987977.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      F6XJJ0
      Conserved Domains (6) summary
      PTZ00322
      Location:644 → 728
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5347
      Location:369 → 599
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:229 → 332
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:640 → 673
      ANK; ANK repeat [structural motif]
      cd08851
      Location:366 → 480
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      cl12013
      Location:1 → 173
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    8. XM_028843238.1 → XP_028699071.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      F6XJJ0
      Conserved Domains (6) summary
      PTZ00322
      Location:644 → 728
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5347
      Location:369 → 599
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:229 → 332
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:640 → 673
      ANK; ANK repeat [structural motif]
      cd08851
      Location:366 → 480
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      cl12013
      Location:1 → 173
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. XM_015132494.2 → XP_014987980.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A5F8ATT4
      Conserved Domains (7) summary
      smart00105
      Location:222 → 337
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:465 → 581
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:82 → 185
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:80 → 181
      PH; PH domain
      pfam12796
      Location:465 → 559
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:493 → 526
      ANK; ANK repeat [structural motif]
      cl12013
      Location:1 → 47
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_003726933.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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