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    MTHFR methylenetetrahydrofolate reductase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714840, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MTHFRprovided by VGNC
    Official Full Name
    methylenetetrahydrofolate reductaseprovided by VGNC
    Primary source
    VGNC:VGNC:75069
    Locus tag
    EGK_00236
    See related
    Ensembl:ENSMMUG00000007828
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MTHFR in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (212654898..212675519)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (11053307..11069756, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene natriuretic peptide B Neighboring gene natriuretic peptide A Neighboring gene chloride voltage-gated channel 6 Neighboring gene uncharacterized protein C1orf167-like Neighboring gene chromosome 1 C1orf167 homolog Neighboring gene splicing factor 3B subunit 4-like Neighboring gene angiotensin II receptor associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methylenetetrahydrofolate reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methylenetetrahydrofolate reductase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      212654898..212675519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001105017.4 → XP_001105017.2  methylenetetrahydrofolate reductase isoform X2

      UniProtKB/TrEMBL
      F7GJ76, H9FUQ0
      Related
      ENSMMUP00000040601.3, ENSMMUT00000047571.3
      Conserved Domains (1) summary
      cl00246
      Location:60 → 626
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    2. XM_028839769.1 → XP_028695602.1  methylenetetrahydrofolate reductase isoform X2

      UniProtKB/TrEMBL
      F7GJ76, H9FUQ0
      Conserved Domains (1) summary
      cl00246
      Location:60 → 626
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    3. XM_015112111.2 → XP_014967597.2  methylenetetrahydrofolate reductase isoform X1

      UniProtKB/TrEMBL
      F7CI98, H9FUQ0
      Related
      ENSMMUP00000010283.4, ENSMMUT00000010963.4
      Conserved Domains (1) summary
      cl00246
      Location:101 → 667
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    4. XM_028839777.1 → XP_028695610.1  methylenetetrahydrofolate reductase isoform X3

      Conserved Domains (1) summary
      cl00246
      Location:1 → 381
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
    Nucleotide Protein
    Heading Accession and Version

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