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    ACTN1 actinin alpha 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 711994, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ACTN1provided by VGNC
    Official Full Name
    actinin alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:69423
    See related
    Ensembl:ENSMMUG00000010767
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ACTN1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (131003053..131111379, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (131033927..131141942, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106999468 Neighboring gene uncharacterized LOC114679588 Neighboring gene golgin-45 pseudogene Neighboring gene barrier-to-autointegration factor pseudogene Neighboring gene DDB1 and CUL4 associated factor 5 Neighboring gene ATP-dependent RNA helicase DDX18 pseudogene Neighboring gene protein SET pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-actinin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      131003053..131111379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015143969.2 → XP_014999455.1  alpha-actinin-1 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QE04, A0A1D5QQQ6
      Related
      ENSMMUP00000046273.2, ENSMMUT00000057360.2
      Conserved Domains (6) summary
      cd00051
      Location:750 → 839
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:395 → 622
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:634 → 733
      Spectrin; Spectrin repeat
      pfam08726
      Location:844 → 910
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:28 → 132
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:136 → 250
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    2. XM_015143971.2 → XP_014999457.1  alpha-actinin-1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5QQQ6, I0FW14
      Related
      ENSMMUP00000051842.1, ENSMMUT00000059424.2
      Conserved Domains (6) summary
      COG5126
      Location:743 → 847
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00176
      Location:395 → 622
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:634 → 733
      Spectrin; Spectrin repeat
      pfam08726
      Location:817 → 883
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:28 → 132
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:136 → 250
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    3. XM_015143970.2 → XP_014999456.1  alpha-actinin-1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QQQ6, F7GV42, H9YUP4
      Related
      ENSMMUP00000014104.3, ENSMMUT00000015052.4
      Conserved Domains (6) summary
      cd00051
      Location:750 → 817
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:395 → 622
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:634 → 733
      Spectrin; Spectrin repeat
      pfam08726
      Location:822 → 888
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:28 → 132
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:136 → 250
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
    Nucleotide Protein
    Heading Accession and Version

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