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    PTPN6 protein tyrosine phosphatase non-receptor type 6 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714374, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PTPN6provided by VGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 6provided by VGNC
    Primary source
    VGNC:VGNC:76607
    See related
    Ensembl:ENSMMUG00000010203
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PTPN6 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (7117057..7134692)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (7261310..7278114)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene chromosome 11 C12orf57 homolog Neighboring gene uncharacterized LOC107000739 Neighboring gene microRNA mir-200c Neighboring gene microRNA mir-141

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 6
    XP_015006430.1
    XP_015006431.1
    XP_015006432.1
    XP_015006433.1
    XP_015006435.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      7117057..7134692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015150945.2 → XP_015006431.1  tyrosine-protein phosphatase non-receptor type 6 isoform X1

      UniProtKB/TrEMBL
      A0A5K1UTD3, H9F6Y5
      Conserved Domains (4) summary
      cd09931
      Location:140 → 246
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:34 → 132
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      smart00194
      Location:274 → 545
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:303 → 545
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. XM_015150946.2 → XP_015006432.1  tyrosine-protein phosphatase non-receptor type 6 isoform X1

      UniProtKB/TrEMBL
      A0A5K1UTD3, H9F6Y5
      Conserved Domains (4) summary
      cd09931
      Location:140 → 246
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:34 → 132
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      smart00194
      Location:274 → 545
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:303 → 545
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    3. XM_015150944.2 → XP_015006430.1  tyrosine-protein phosphatase non-receptor type 6 isoform X1

      UniProtKB/TrEMBL
      A0A5K1UTD3, H9F6Y5
      Related
      ENSMMUP00000013344.4, ENSMMUT00000014247.4
      Conserved Domains (4) summary
      cd09931
      Location:140 → 246
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:34 → 132
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      smart00194
      Location:274 → 545
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:303 → 545
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    4. XM_015150947.2 → XP_015006433.1  tyrosine-protein phosphatase non-receptor type 6 isoform X2

      UniProtKB/TrEMBL
      H9F6Y5
      Related
      ENSMMUP00000061003.2, ENSMMUT00000076803.2
      Conserved Domains (3) summary
      cd09931
      Location:111 → 217
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:6 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd00047
      Location:274 → 516
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    5. XM_015150949.2 → XP_015006435.1  tyrosine-protein phosphatase non-receptor type 6 isoform X3

      UniProtKB/TrEMBL
      F6SIM1, F6SIN0, H9F6Y5, I0FMS6
      Related
      ENSMMUP00000013343.4, ENSMMUT00000014246.4
      Conserved Domains (3) summary
      cd09931
      Location:109 → 215
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:3 → 101
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd00047
      Location:272 → 514
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein
    Heading Accession and Version

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