TTN titin [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Gene symbol: TTN
Gene description: titin
See related: Ensembl:ENSMMUG00000009038
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 340

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	12	NC_041765.1 (65655525..65928956, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	12	NC_027904.1 (65607219..65880619, complement)

Chromosome 12 - NC_041765.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

TTN_3879 (e-PCR)
- UniSTS:462604

SHGC-62013 (e-PCR)
- UniSTS:27408

RH48674 (e-PCR)
- UniSTS:32026

RH65366 (e-PCR)
- UniSTS:73247

D2S385 (e-PCR), detects polymorphism
- UniSTS:50480

RH44253 (e-PCR)
- UniSTS:31799

D2S1524E (e-PCR)
- UniSTS:45880

TTN-1 (e-PCR)
- UniSTS:254009

A004O05 (e-PCR)
- UniSTS:81724

RH65766 (e-PCR)
- UniSTS:17479

D2S1518E (e-PCR)
- UniSTS:150612

D2S1532E (e-PCR)
- UniSTS:150620

D2S1540E (e-PCR)
- UniSTS:150626

D2S1546E (e-PCR)
- UniSTS:150631

D2S1550E (e-PCR)
- UniSTS:150635

RH98821 (e-PCR)
- UniSTS:85869

D2S1553E (e-PCR)
- UniSTS:150638

D2S1555E (e-PCR)
- UniSTS:150640

D2S1560E (e-PCR)
- UniSTS:150645

D2S1564E (e-PCR)
- UniSTS:150649

D2S1570E (e-PCR)
- UniSTS:150654

D2S1571E (e-PCR)
- UniSTS:150655

D2S1572E (e-PCR)
- UniSTS:150656

D2S1580E (e-PCR)
- UniSTS:150664

RH78892 (e-PCR)
- UniSTS:398

A008T22 (e-PCR)
- UniSTS:24210

D2S1591E (e-PCR)
- UniSTS:150675

D2S1593E (e-PCR)
- UniSTS:150677

RH65621 (e-PCR)
- UniSTS:70042

D2S324 (e-PCR), detects polymorphism
- UniSTS:76702

WI-10343 (e-PCR)
- UniSTS:29854

RH65575 (e-PCR)
- UniSTS:58532

MARC_23497-23498:1027358865:1 (e-PCR)
- UniSTS:268713

D2S1519E (e-PCR)
- UniSTS:22697

REN90109 (e-PCR)
- UniSTS:414907

G59490 (e-PCR)
- UniSTS:136654

D2S1881 (e-PCR)
- UniSTS:153573

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: titin

XP_014965943.2

EC 2.7.11.1

XP_014965944.2

EC 2.7.11.1

XP_014965945.2

EC 2.7.11.1

XP_028686722.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041765.1 Reference Mmul_10 Primary Assembly

Range

65655525..65928956 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028830889.1 → XP_028686722.1 titin isoform X1

UniProtKB/TrEMBL

F7FBM0

Related

ENSMMUP00000011868.4, ENSMMUT00000012655.4

Conserved Domains (16) summary

cd05747
Location:34188 → 34279

Ig_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar domains

PTZ00121
Location:9961 → 10655

PTZ00121; MAEBL; Provisional

smart00060
Location:17128 → 17212

FN3; Fibronectin type 3 domain

smart00410
Location:14101 → 14165

IG_like; Immunoglobulin like

PHA03247
Location:11414 → 11729

PHA03247; large tegument protein UL36; Provisional

COG0810
Location:11243 → 11321

TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]

PRK10811
Location:11925 → 12142

rne; ribonuclease E; Reviewed

PRK10819
Location:11756 → 11865

PRK10819; transport protein TonB; Provisional

PRK12323
Location:254 → 359

PRK12323; DNA polymerase III subunits gamma and tau; Provisional

cd00063
Location:23285 → 23377

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:32880 → 33156

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

cd05748
Location:21629 → 21702

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains

pfam02818
Location:10926 → 10952

PPAK; PPAK motif

pfam07679
Location:8889 → 8978

I-set; Immunoglobulin I-set domain

pfam13927
Location:12850 → 12918

Ig_3; Immunoglobulin domain

cl11960
Location:26354 → 26428

Ig; Immunoglobulin domain
XM_015110457.2 → XP_014965943.2 titin isoform X2

Conserved Domains (10) summary

cd05747
Location:26108 → 26199

Ig_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar domains

PTZ00121
Location:413 → 725

PTZ00121; MAEBL; Provisional

smart00060
Location:9048 → 9132

FN3; Fibronectin type 3 domain

smart00410
Location:6021 → 6085

IG_like; Immunoglobulin like

cd00063
Location:15205 → 15297

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:24800 → 25076

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

cd05748
Location:13549 → 13622

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains

pfam07679
Location:6 → 97

I-set; Immunoglobulin I-set domain

pfam13927
Location:4770 → 4838

Ig_3; Immunoglobulin domain

cl11960
Location:18274 → 18348

Ig; Immunoglobulin domain
XM_015110458.2 → XP_014965944.2 titin isoform X3

Conserved Domains (9) summary

cd05747
Location:26061 → 26152

Ig_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar domains

smart00060
Location:9001 → 9085

FN3; Fibronectin type 3 domain

smart00410
Location:5974 → 6038

IG_like; Immunoglobulin like

cd00063
Location:15158 → 15250

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:24753 → 25029

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

cd05748
Location:13502 → 13575

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains

pfam07679
Location:6 → 97

I-set; Immunoglobulin I-set domain

pfam13927
Location:4723 → 4791

Ig_3; Immunoglobulin domain

cl11960
Location:18227 → 18301

Ig; Immunoglobulin domain
XM_015110459.2 → XP_014965945.2 titin isoform X4

Conserved Domains (3) summary

PTZ00121
Location:413 → 724

PTZ00121; MAEBL; Provisional

PRK12323
Location:254 → 359

PRK12323; DNA polymerase III subunits gamma and tau; Provisional

pfam07679
Location:6 → 97

I-set; Immunoglobulin I-set domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001321008.1: Suppressed sequence

Description

NM_001321008.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: TTN (GeneID:7273).