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    ERN1 endoplasmic reticulum to nucleus signaling 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 717751, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ERN1provided by VGNC
    Official Full Name
    endoplasmic reticulum to nucleus signaling 1provided by VGNC
    Primary source
    VGNC:VGNC:72429
    See related
    Ensembl:ENSMMUG00000015185
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ERN1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (60594802..60686360, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (57654333..57745270, complement)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene proline rich 29 Neighboring gene intercellular adhesion molecule 2 Neighboring gene uncharacterized LOC106994091 Neighboring gene small nucleolar RNA SNORD104 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene testis expressed 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of IRE1-TRAF2-ASK1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase/endoribonuclease IRE1
    XP_001109583.2
    XP_014975584.1
    XP_014975585.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      60594802..60686360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015120098.2 → XP_014975584.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      UniProtKB/TrEMBL
      A0A5F8A6W0, G7NJ93
      Related
      ENSMMUP00000073590.1, ENSMMUT00000108845.1
      Conserved Domains (5) summary
      cd09769
      Location:31 → 265
      Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
      cd10422
      Location:803 → 928
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      smart00220
      Location:538 → 799
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13982
      Location:535 → 800
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      pfam13360
      Location:22 → 192
      PQQ_2; PQQ-like domain

    2. XM_015120099.2 → XP_014975585.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

      UniProtKB/TrEMBL
      G7NJ93
      Conserved Domains (5) summary
      cd09769
      Location:31 → 299
      Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
      cd10422
      Location:773 → 898
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      smart00220
      Location:508 → 769
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13982
      Location:505 → 770
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      pfam13360
      Location:22 → 221
      PQQ_2; PQQ-like domain

    3. XM_001109583.4 → XP_001109583.2  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1

      See identical proteins and their annotated locations for XP_001109583.2

      UniProtKB/TrEMBL
      F6WBI3, G7NJ93
      Related
      ENSMMUP00000019914.3, ENSMMUT00000021295.4
      Conserved Domains (5) summary
      cd09769
      Location:31 → 299
      Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
      cd10422
      Location:837 → 962
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      smart00220
      Location:572 → 833
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13982
      Location:569 → 834
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      pfam13360
      Location:22 → 221
      PQQ_2; PQQ-like domain
    Nucleotide Protein
    Heading Accession and Version

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