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    IDO1 indoleamine 2,3-dioxygenase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574370, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IDO1provided by VGNC
    Official Full Name
    indoleamine 2,3-dioxygenase 1provided by VGNC
    Primary source
    VGNC:VGNC:73580
    See related
    Ensembl:ENSMMUG00000019304
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    INDO
    Orthologs
    human mouse all
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    Genomic context

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    See IDO1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (40503015..40518713)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (40457840..40473496)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 18 Neighboring gene serine/arginine-rich splicing factor 3 Neighboring gene ADAM metallopeptidase domain 2 Neighboring gene succinate dehydrogenase cytochrome b560 subunit, mitochondrial Neighboring gene nuclear transcription factor Y subunit beta pseudogene Neighboring gene indoleamine 2,3-dioxygenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains. Burudi EM, et al. J Virol, 2002 Dec. PMID 12414962, Free PMC Article
    2. TGF-beta in intestinal lymphoid organs contributes to the death of armed effector CD8 T cells and is associated with the absence of virus containment in rhesus macaques infected with the simian immunodeficiency virus. Cumont MC, et al. Cell Death Differ, 2007 Oct. PMID 17612589
    3. Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human. Magness CL, et al. Genome Biol, 2005. PMID 15998449, Free PMC Article
    4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8+ T cells from mesentric lymph nodes.
      Title: TGF-beta in intestinal lymphoid organs contributes to the death of armed effector CD8 T cells and is associated with the absence of virus containment in rhesus macaques infected with the simian immunodeficiency virus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables indoleamine 2,3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tryptophan 2,3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    indoleamine 2,3-dioxygenase 1
    Names
    indoleamine-pyrrole 2,3 dioxygenase
    NP_001070951.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077483.1 → NP_001070951.1  indoleamine 2,3-dioxygenase 1

      Status: PROVISIONAL

      Source sequence(s)
      CO583435, CO648840
      UniProtKB/TrEMBL
      F6SGT6, G7MZ59
      Related
      ENSMMUP00000032133.3, ENSMMUT00000039050.3
      Conserved Domains (1) summary
      pfam01231
      Location:13 → 395
      IDO; Indoleamine 2,3-dioxygenase

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      40503015..40518713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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