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    HDAC5 histone deacetylase 5 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 711456, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HDAC5provided by VGNC
    Official Full Name
    histone deacetylase 5provided by VGNC
    Primary source
    VGNC:VGNC:73166
    See related
    Ensembl:ENSMMUG00000006806
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HDAC5 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (55331843..55380169, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (49940558..49989067, complement)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene LSM12 homolog Neighboring gene glucose-6-phosphatase catalytic subunit 3 Neighboring gene homologous recombination factor with OB-fold Neighboring gene ankyrin repeat and SOCS box containing 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone deacetylase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone deacetylase 5
    NP_001245027.1
    XP_014975211.1
    XP_014975212.1
    XP_014975213.1
    XP_014975215.1
    XP_014975216.1
    XP_014975217.1
    XP_014975218.1
    XP_014975219.1
    XP_028691440.1
    XP_028691441.1
    XP_028691442.1
    XP_028691443.1
    XP_028691444.1
    XP_028691445.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258098.1 → NP_001245027.1  histone deacetylase 5

      See identical proteins and their annotated locations for NP_001245027.1

      Status: PROVISIONAL

      Source sequence(s)
      JU470486
      UniProtKB/TrEMBL
      F7GZL0, H9YUC4
      Related
      ENSMMUP00000061782.1, ENSMMUT00000106703.1
      Conserved Domains (2) summary
      cd10164
      Location:69 → 165
      ClassIIa_HDAC5_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase
      cd10007
      Location:680 → 1096
      HDAC5; Histone deacetylase 5

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      55331843..55380169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015119730.2 → XP_014975216.1  histone deacetylase 5 isoform X7

      UniProtKB/TrEMBL
      H9FNB9
      Conserved Domains (2) summary
      cd10007
      Location:670 → 1086
      HDAC5; Histone deacetylase 5
      cl23765
      Location:68 → 155
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. XM_015119726.2 → XP_014975212.1  histone deacetylase 5 isoform X5

      UniProtKB/TrEMBL
      F7GZL0
      Conserved Domains (2) summary
      cd10164
      Location:68 → 164
      ClassIIa_HDAC5_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase
      cd10007
      Location:679 → 1095
      HDAC5; Histone deacetylase 5

    3. XM_015119729.2 → XP_014975215.1  histone deacetylase 5 isoform X6

      UniProtKB/TrEMBL
      H9FNB9
      Conserved Domains (2) summary
      cd10007
      Location:671 → 1087
      HDAC5; Histone deacetylase 5
      cl23765
      Location:69 → 156
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    4. XM_015119732.2 → XP_014975218.1  histone deacetylase 5 isoform X8

      UniProtKB/TrEMBL
      A0A1D5QK54, A0A1D5RD12, F7GZK7
      Related
      ENSMMUP00000048427.2, ENSMMUT00000071045.2
      Conserved Domains (2) summary
      cd10164
      Location:27 → 123
      ClassIIa_HDAC5_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase
      cd10007
      Location:638 → 1054
      HDAC5; Histone deacetylase 5

    5. XM_015119731.2 → XP_014975217.1  histone deacetylase 5 isoform X8

      UniProtKB/TrEMBL
      A0A1D5QK54, A0A1D5RD12, F7GZK7
      Related
      ENSMMUP00000063065.1, ENSMMUT00000097870.1
      Conserved Domains (2) summary
      cd10164
      Location:27 → 123
      ClassIIa_HDAC5_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase
      cd10007
      Location:638 → 1054
      HDAC5; Histone deacetylase 5

    6. XM_015119727.2 → XP_014975213.1  histone deacetylase 5 isoform X5

      UniProtKB/TrEMBL
      F7GZL0
      Conserved Domains (2) summary
      cd10164
      Location:68 → 164
      ClassIIa_HDAC5_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase
      cd10007
      Location:679 → 1095
      HDAC5; Histone deacetylase 5

    7. XM_015119725.2 → XP_014975211.1  histone deacetylase 5 isoform X4

      UniProtKB/TrEMBL
      F7GZL0, H9YUC4
      Conserved Domains (2) summary
      cd10164
      Location:69 → 165
      ClassIIa_HDAC5_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase
      cd10007
      Location:680 → 1096
      HDAC5; Histone deacetylase 5

    8. XM_028835611.1 → XP_028691444.1  histone deacetylase 5 isoform X9

      UniProtKB/TrEMBL
      A0A1D5RJ53
      Conserved Domains (2) summary
      cd10164
      Location:98 → 194
      ClassIIa_HDAC5_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase
      cd10007
      Location:709 → 1125
      HDAC5; Histone deacetylase 5

    9. XM_028835612.1 → XP_028691445.1  histone deacetylase 5 isoform X10

      UniProtKB/TrEMBL
      A0A1D5RJ53
      Conserved Domains (2) summary
      cd10007
      Location:771 → 1187
      HDAC5; Histone deacetylase 5
      cl25407
      Location:174 → 261
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

    10. XM_028835609.1 → XP_028691442.1  histone deacetylase 5 isoform X3

      UniProtKB/TrEMBL
      A0A1D5RJ53
      Conserved Domains (2) summary
      cd10007
      Location:776 → 1192
      HDAC5; Histone deacetylase 5
      cl25407
      Location:174 → 261
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

    11. XM_028835608.1 → XP_028691441.1  histone deacetylase 5 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RJ53
      Conserved Domains (2) summary
      cd10164
      Location:174 → 270
      ClassIIa_HDAC5_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase
      cd10007
      Location:780 → 1196
      HDAC5; Histone deacetylase 5

    12. XM_028835607.1 → XP_028691440.1  histone deacetylase 5 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RJ53
      Conserved Domains (2) summary
      cd10164
      Location:174 → 270
      ClassIIa_HDAC5_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase
      cd10007
      Location:785 → 1201
      HDAC5; Histone deacetylase 5

    13. XM_028835610.1 → XP_028691443.1  histone deacetylase 5 isoform X8

      UniProtKB/TrEMBL
      A0A1D5QK54, A0A1D5RD12, F7GZK7
      Conserved Domains (2) summary
      cd10164
      Location:27 → 123
      ClassIIa_HDAC5_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase
      cd10007
      Location:638 → 1054
      HDAC5; Histone deacetylase 5

    14. XM_015119733.2 → XP_014975219.1  histone deacetylase 5 isoform X8

      UniProtKB/TrEMBL
      A0A1D5QK54, A0A1D5RD12, F7GZK7
      Conserved Domains (2) summary
      cd10164
      Location:27 → 123
      ClassIIa_HDAC5_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase
      cd10007
      Location:638 → 1054
      HDAC5; Histone deacetylase 5
    Nucleotide Protein
    Heading Accession and Version

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