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    FZD4 frizzled class receptor 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 704754, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FZD4provided by VGNC
    Official Full Name
    frizzled class receptor 4provided by VGNC
    Primary source
    VGNC:VGNC:72836
    See related
    Ensembl:ENSMMUG00000004048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See FZD4 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (80124870..80162526, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (79479436..79516529, complement)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene MOB-like protein phocein pseudogene Neighboring gene olfactory receptor 7E24-like Neighboring gene heterogeneous nuclear ribonucleoprotein C-like Neighboring gene transmembrane protein 135 Neighboring gene E3 ubiquitin-protein ligase XIAP pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Wnt receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables Wnt-protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in non-canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in retina vasculature morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    frizzled-4
    Names
    frizzled 4, seven transmembrane spanning receptor
    frizzled family receptor 4
    frizzled homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266875.1 → NP_001253804.1  frizzled-4 precursor

      See identical proteins and their annotated locations for NP_001253804.1

      Status: PROVISIONAL

      Source sequence(s)
      JV636397
      UniProtKB/TrEMBL
      A0A1D5Q1B1, A0A5F7ZNQ5
      Related
      ENSMMUP00000041823.1, ENSMMUT00000058422.2
      Conserved Domains (2) summary
      cd07448
      Location:42 → 167
      CRD_FZ4; Cysteine-rich Wnt-binding domain of the frizzled 4 (Fz4) receptor
      cd15038
      Location:209 → 509
      7tmF_FZD4; class F frizzled subfamily 4, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      80124870..80162526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015115299.2 → XP_014970785.1  frizzled-4 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZNQ5, A0A5F8AC06
      Related
      ENSMMUP00000074500.1, ENSMMUT00000107176.1
      Conserved Domains (2) summary
      cd07448
      Location:42 → 167
      CRD_FZ4; Cysteine-rich Wnt-binding domain of the frizzled 4 (Fz4) receptor
      pfam01534
      Location:210 → 509
      Frizzled; Frizzled/Smoothened family membrane region

    2. XM_028832624.1 → XP_028688457.1  frizzled-4 isoform X2

      UniProtKB/TrEMBL
      G7NBE7
      Conserved Domains (2) summary
      cd07448
      Location:1 → 116
      CRD_FZ4; Cysteine-rich Wnt-binding domain of the frizzled 4 (Fz4) receptor
      cd15038
      Location:158 → 458
      7tmF_FZD4; class F frizzled subfamily 4, member of 7-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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