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    FGFR1 fibroblast growth factor receptor 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 700126, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FGFR1provided by VGNC
    Official Full Name
    fibroblast growth factor receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:72651
    Locus tag
    EGK_18861
    See related
    Ensembl:ENSMMUG00000022478
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See FGFR1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (38876231..38935970, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (38693416..38751421, complement)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase 5 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene skin secretory protein xP2-like Neighboring gene long intergenic non-protein coding RNA 3042 Neighboring gene uncharacterized LOC106999739

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor receptor 1
    Names
    basic fibroblast growth factor receptor 1
    NP_001253576.1
    XP_015000545.1
    XP_015000546.1
    XP_015000547.1
    XP_015000548.1
    XP_015000549.1
    XP_015000550.1
    XP_015000551.1
    XP_015000552.1
    XP_015000553.1
    XP_015000554.1
    XP_015000555.1
    XP_028707990.1
    XP_028707991.1
    XP_028707992.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266647.1 → NP_001253576.1  fibroblast growth factor receptor 1 precursor

      See identical proteins and their annotated locations for NP_001253576.1

      Status: PROVISIONAL

      Source sequence(s)
      JV045177
      UniProtKB/TrEMBL
      F7A4T4, H9FRD4
      Conserved Domains (5) summary
      cd05098
      Location:373 → 674
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam18123
      Location:280 → 309
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:164 → 167
      Ig; Ig strand A [structural motif]
      cd05857
      Location:62 → 156
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:164 → 268
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      38876231..38935970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015145061.2 → XP_015000547.1  fibroblast growth factor receptor 1 isoform X7

      UniProtKB/TrEMBL
      F7A4T4
      Conserved Domains (7) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd04974
      Location:270 → 359
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:163 → 247
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00410
      Location:262 → 358
      IG_like; Immunoglobulin like
      pfam07679
      Location:160 → 247
      I-set; Immunoglobulin I-set domain
      cd05098
      Location:462 → 763
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam07714
      Location:476 → 752
      Pkinase_Tyr; Protein tyrosine kinase

    2. XM_015145064.2 → XP_015000550.1  fibroblast growth factor receptor 1 isoform X6

      UniProtKB/TrEMBL
      F7A4R9, F7A4T4
      Related
      ENSMMUP00000029573.4, ENSMMUT00000031612.4
      Conserved Domains (5) summary
      cd05098
      Location:371 → 672
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam18123
      Location:280 → 309
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:164 → 167
      Ig; Ig strand A [structural motif]
      cd05857
      Location:62 → 156
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:164 → 268
      Ig; Immunoglobulin domain

    3. XM_015145059.2 → XP_015000545.1  fibroblast growth factor receptor 1 isoform X1

      UniProtKB/TrEMBL
      F7A4T4, G7MZ50
      Conserved Domains (7) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd04974
      Location:270 → 359
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:163 → 247
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00410
      Location:262 → 358
      IG_like; Immunoglobulin like
      pfam07679
      Location:160 → 247
      I-set; Immunoglobulin I-set domain
      cd05098
      Location:464 → 765
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam07714
      Location:478 → 754
      Pkinase_Tyr; Protein tyrosine kinase

    4. XM_028852157.1 → XP_028707990.1  fibroblast growth factor receptor 1 isoform X3

      UniProtKB/TrEMBL
      F7A4T4
      Related
      ENSMMUP00000029572.4, ENSMMUT00000031611.4
      Conserved Domains (4) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161 → 245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268 → 357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05098
      Location:460 → 761
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

    5. XM_015145060.2 → XP_015000546.1  fibroblast growth factor receptor 1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5Q279, A0A1D5QRY4, F7A4T4
      Related
      ENSMMUP00000050812.2, ENSMMUT00000072906.2
      Conserved Domains (4) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161 → 245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268 → 357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05098
      Location:462 → 763
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

    6. XM_015145063.2 → XP_015000549.1  fibroblast growth factor receptor 1 isoform X5

      UniProtKB/TrEMBL
      F7A4T4
      Conserved Domains (5) summary
      cd05098
      Location:373 → 674
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam18123
      Location:282 → 311
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:166 → 169
      Ig; Ig strand A [structural motif]
      cd05857
      Location:64 → 158
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:166 → 270
      Ig; Immunoglobulin domain

    7. XM_015145062.2 → XP_015000548.1  fibroblast growth factor receptor 1 isoform X4

      UniProtKB/TrEMBL
      F7A4T4
      Conserved Domains (5) summary
      cd05098
      Location:375 → 676
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam18123
      Location:282 → 311
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:166 → 169
      Ig; Ig strand A [structural motif]
      cd05857
      Location:64 → 158
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:166 → 270
      Ig; Immunoglobulin domain

    8. XM_028852158.1 → XP_028707991.1  fibroblast growth factor receptor 1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5Q279, A0A1D5QRY4, F7A4T4
      Related
      ENSMMUP00000042141.2, ENSMMUT00000071294.2
      Conserved Domains (4) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161 → 245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268 → 357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05098
      Location:462 → 763
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

    9. XM_028852159.1 → XP_028707992.1  fibroblast growth factor receptor 1 isoform X3

      UniProtKB/TrEMBL
      F7A4T4
      Conserved Domains (4) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161 → 245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268 → 357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05098
      Location:460 → 761
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

    10. XM_015145067.2 → XP_015000553.1  fibroblast growth factor receptor 1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5Q279, A0A1D5QRY4, F7A4T4
      Conserved Domains (4) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161 → 245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268 → 357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05098
      Location:462 → 763
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

    11. XM_015145065.2 → XP_015000551.1  fibroblast growth factor receptor 1 isoform X1

      UniProtKB/TrEMBL
      F7A4T4, G7MZ50
      Conserved Domains (7) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd04974
      Location:270 → 359
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:163 → 247
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00410
      Location:262 → 358
      IG_like; Immunoglobulin like
      pfam07679
      Location:160 → 247
      I-set; Immunoglobulin I-set domain
      cd05098
      Location:464 → 765
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam07714
      Location:478 → 754
      Pkinase_Tyr; Protein tyrosine kinase

    12. XM_015145068.2 → XP_015000554.1  fibroblast growth factor receptor 1 isoform X4

      UniProtKB/TrEMBL
      F7A4T4
      Conserved Domains (5) summary
      cd05098
      Location:375 → 676
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam18123
      Location:282 → 311
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:166 → 169
      Ig; Ig strand A [structural motif]
      cd05857
      Location:64 → 158
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:166 → 270
      Ig; Immunoglobulin domain

    13. XM_015145069.2 → XP_015000555.1  fibroblast growth factor receptor 1 isoform X8

      UniProtKB/TrEMBL
      F7A4T4, H9FRD4
      Conserved Domains (5) summary
      cd05098
      Location:373 → 674
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam18123
      Location:280 → 309
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:164 → 167
      Ig; Ig strand A [structural motif]
      cd05857
      Location:62 → 156
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:164 → 268
      Ig; Immunoglobulin domain

    14. XM_015145066.2 → XP_015000552.1  fibroblast growth factor receptor 1 isoform X1

      UniProtKB/TrEMBL
      F7A4T4, G7MZ50
      Conserved Domains (7) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd04974
      Location:270 → 359
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:163 → 247
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00410
      Location:262 → 358
      IG_like; Immunoglobulin like
      pfam07679
      Location:160 → 247
      I-set; Immunoglobulin I-set domain
      cd05098
      Location:464 → 765
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam07714
      Location:478 → 754
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein
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