NLRP8 NLR family pyrin domain containing 8 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: NLRP8provided by VGNC
Official Full Name: NLR family pyrin domain containing 8provided by VGNC
Primary source: VGNC:VGNC:75232
See related: Ensembl:ENSMMUG00000009935
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human all
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Genomic context

Location:: chromosome: 19

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	19	NC_041772.1 (55708888..55757555)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	19	NC_027911.1 (53140106..53189705, complement)

Chromosome 19 - NC_041772.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 8

Names: NLR family pyrin domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114115.1 → NP_001107587.1 NACHT, LRR and PYD domains-containing protein 8

See identical proteins and their annotated locations for NP_001107587.1

Status: PROVISIONAL

Source sequence(s)

EU340330

UniProtKB/TrEMBL

B0FNB1, F6Y4E6

Related

ENSMMUP00000012994.4, ENSMMUT00000013870.4

Conserved Domains (6) summary

smart00382
Location:202 → 311

AAA; ATPases associated with a variety of cellular activities

COG4886
Location:814 → 990

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:782 → 1018

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08320
Location:41 → 123

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00034
Location:789 → 816

LRR_AMN1; leucine-rich repeat [structural motif]

cl21455
Location:205 → 370

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041772.1 Reference Mmul_10 Primary Assembly

Range

55708888..55757555

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028838300.1 → XP_028694133.1 NACHT, LRR and PYD domains-containing protein 8 isoform X1

UniProtKB/TrEMBL

F6Y4E6

Conserved Domains (4) summary

cd08320
Location:41 → 123

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00034
Location:789 → 816

LRR_AMN1; leucine-rich repeat [structural motif]

cl21455
Location:205 → 370

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl29113
Location:782 → 1006

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...