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    CFLAR CASP8 and FADD like apoptosis regulator [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574234, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CFLARprovided by VGNC
    Official Full Name
    CASP8 and FADD like apoptosis regulatorprovided by VGNC
    Primary source
    VGNC:VGNC:71019
    Locus tag
    EGK_04680
    See related
    Ensembl:ENSMMUG00000012310
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CFLAR in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (88378248..88425643)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (82617474..82666243)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene inosine-5'-monophosphate dehydrogenase 1 pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC106992695 Neighboring gene 60S ribosomal protein L38 pseudogene Neighboring gene caspase 10 Neighboring gene protein shisa-5 pseudogene Neighboring gene caspase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CASP8 and FADD-like apoptosis regulator
    Names
    flice/caspase-i inhibitory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      88378248..88425643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015110712.2 → XP_014966198.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      A0A8J8XP41, F7BBV9, F7DL90, F7DL95, G7N8M8, H9FN52
      Related
      ENSMMUP00000073792.1, ENSMMUT00000082111.1
      Conserved Domains (3) summary
      smart00115
      Location:244 → 479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:1 → 80
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91 → 171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    2. XM_028830972.1 → XP_028686805.1  CASP8 and FADD-like apoptosis regulator isoform X2

      UniProtKB/TrEMBL
      F7DGQ2, F7DL90
      Related
      ENSMMUP00000016150.3, ENSMMUT00000017246.4
      Conserved Domains (3) summary
      cd08337
      Location:1 → 80
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91 → 171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:244 → 433
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    3. XM_015110718.2 → XP_014966204.2  CASP8 and FADD-like apoptosis regulator isoform X5

      UniProtKB/TrEMBL
      F7DGN6, H9ZEV1
      Related
      ENSMMUP00000016153.4, ENSMMUT00000017249.4
      Conserved Domains (2) summary
      cd08337
      Location:1 → 80
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91 → 171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    4. XM_015110713.2 → XP_014966199.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      A0A8J8XP41, F7BBV9, F7DL90, F7DL95, G7N8M8, H9FN52
      Related
      ENSMMUP00000037902.3, ENSMMUT00000044879.3
      Conserved Domains (3) summary
      smart00115
      Location:244 → 479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:1 → 80
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91 → 171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    5. XM_015110711.2 → XP_014966197.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      A0A8J8XP41, F7BBV9, F7DL90, F7DL95, G7N8M8, H9FN52
      Related
      ENSMMUP00000016147.4, ENSMMUT00000017243.4
      Conserved Domains (3) summary
      smart00115
      Location:244 → 479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:1 → 80
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91 → 171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    6. XM_015110716.2 → XP_014966202.1  CASP8 and FADD-like apoptosis regulator isoform X4

      Conserved Domains (1) summary
      smart00115
      Location:1 → 234
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

    7. XM_028830973.1 → XP_028686806.1  CASP8 and FADD-like apoptosis regulator isoform X3

      Conserved Domains (1) summary
      smart00115
      Location:56 → 291
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    Nucleotide Protein
    Heading Accession and Version

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