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    NGLY1 N-glycanase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 700842, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NGLY1provided by VGNC
    Official Full Name
    N-glycanase 1provided by VGNC
    Primary source
    VGNC:VGNC:75200
    See related
    Ensembl:ENSMMUG00000014790
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NGLY1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (21878277..21946076)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (182528727..182603090, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 3B Neighboring gene ribulose-phosphate 3-epimerase-like Neighboring gene transcription initiation factor TFIID subunit 9B pseudogene Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene cysteine-rich protein 1 pseudogene Neighboring gene 3-oxoacyl-ACP synthase, mitochondrial Neighboring gene U4 spliceosomal RNA Neighboring gene DNA topoisomerase II beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycoprotein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein deglycosylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein quality control for misfolded or incompletely synthesized proteins IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
    XP_014987784.1
    XP_014987786.1
    XP_014987788.1
    XP_028699460.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      21878277..21946076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015132298.2 → XP_014987784.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X1

      UniProtKB/TrEMBL
      F6WC45, H9F5X1
      Related
      ENSMMUP00000019420.3, ENSMMUT00000020754.4
      Conserved Domains (5) summary
      cd10459
      Location:19 → 109
      PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
      COG1305
      Location:293 → 354
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam01841
      Location:275 → 354
      Transglut_core; Transglutaminase-like superfamily
      pfam03835
      Location:338 → 391
      Rad4; Rad4 transglutaminase-like domain
      pfam04721
      Location:457 → 651
      PAW; PNGase C-terminal domain, mannose-binding module PAW

    2. XM_028843627.1 → XP_028699460.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X3

      UniProtKB/TrEMBL
      H9F5X1
      Conserved Domains (4) summary
      cd10459
      Location:19 → 109
      PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
      pfam03835
      Location:338 → 391
      Rad4; Rad4 transglutaminase-like domain
      pfam04721
      Location:457 → 589
      PAW; PNGase C-terminal domain, mannose-binding module PAW
      pfam01841
      Location:275 → 354
      Transglut_core; Transglutaminase-like superfamily

    3. XM_015132300.2 → XP_014987786.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2

      UniProtKB/TrEMBL
      F6WCT2, H9F5X1
      Related
      ENSMMUP00000019418.4, ENSMMUT00000020752.4
      Conserved Domains (5) summary
      cd10459
      Location:19 → 109
      PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
      COG1305
      Location:293 → 354
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam01841
      Location:275 → 354
      Transglut_core; Transglutaminase-like superfamily
      pfam03835
      Location:338 → 424
      Rad4; Rad4 transglutaminase-like domain
      pfam04721
      Location:416 → 596
      PAW; PNGase C-terminal domain, mannose-binding module PAW

    4. XM_015132302.1 → XP_014987788.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X4

      UniProtKB/TrEMBL
      H9F5X1
      Conserved Domains (5) summary
      cd10459
      Location:19 → 109
      PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
      COG1305
      Location:293 → 354
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam01841
      Location:275 → 354
      Transglut_core; Transglutaminase-like superfamily
      pfam03835
      Location:338 → 391
      Rad4; Rad4 transglutaminase-like domain
      cl10509
      Location:457 → 538
      PAW; PNGase C-terminal domain, mannose-binding module PAW
    Nucleotide Protein
    Heading Accession and Version

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