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    mec-9 Kunitz/Bovine pancreatic trypsin inhibitor domain protein [ Caenorhabditis elegans ]

    Gene ID: 179382, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mec-9
    Official Full Name
    Kunitz/Bovine pancreatic trypsin inhibitor domain protein
    Primary source
    WormBase:WBGene00003173
    Locus tag
    CELE_C50H2.3
    See related
    AllianceGenome:WB:WBGene00003173
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; positive regulation of detection of mechanical stimulus involved in sensory perception of touch; and positive regulation of mechanosensory behavior. Predicted to be located in extracellular region. Is expressed in PVDL; PVDR; head neurons; touch receptor neurons; and ventral cord neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mec-9 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    19
    Sequence:
    Chromosome: V; NC_003283.11 (9907615..9915121, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene putative G-protein coupled receptor egl-47 Neighboring gene ncRNA Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene ncRNA Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Homeobox domain-containing protein Neighboring gene HEPN domain-containing protein Neighboring gene Homeobox domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extracellular proteins needed for C. elegans mechanosensation. Du H, et al. Neuron, 1996 Jan. PMID 8562083
    2. The ion channels to cytoskeleton connection as potential mechanism of mechanosensitivity. Martinac B. Biochim Biophys Acta, 2014 Feb. PMID 23886913
    3. The C. elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1. Jia Y, et al. Development, 1997 May. PMID 9169852
    4. Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Kim N, et al. Genetics, 2007 Oct. PMID 17720915, Free PMC Article
    5. Analysis of the role of Caenorhabditis elegans GC-AG introns in regulated splicing. Farrer T, et al. Nucleic Acids Res, 2002 Aug 1. PMID 12140320, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of mechanical stimulus involved in sensory perception of touch IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mechanosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mechanosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kunitz/Bovine pancreatic trypsin inhibitor domain protein
    NP_001256153.1
    • Confirmed by transcript evidence
    NP_001256154.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9907615..9915121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269225.3 → NP_001256154.1  Kunitz/Bovine pancreatic trypsin inhibitor domain protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MVG9
      Conserved Domains (3) summary
      smart00131
      Location:124 → 180
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00054
      Location:214 → 250
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:303 → 335
      EGF; EGF-like domain

    2. NM_001269224.3 → NP_001256153.1  Kunitz/Bovine pancreatic trypsin inhibitor domain protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECK0, Q18761
      Conserved Domains (6) summary
      smart00131
      Location:460 → 516
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00054
      Location:550 → 586
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:639 → 671
      EGF; EGF-like domain
      pfam00014
      Location:35 → 87
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam07645
      Location:199 → 238
      EGF_CA; Calcium-binding EGF domain
      pfam12947
      Location:283 → 318
      EGF_3; EGF domain
    Nucleotide Protein
    Heading Accession and Version

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